ArticleMagnetic resonance in medicine2020
Mapping hepatocyte size in vivo using temporal diffusion spectroscopy MRI.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
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- Time-dependent diffusion MRI for differentiating non‑small cell lung‑cancer brain metastases from breast‑cancer brain metastases and gliomas.Neuroradiology · 2026Article
- Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers.Magnetic resonance imaging · 2026Article
- Integrating C-reactive protein flare and early MRI dynamics for enhanced prediction of immunotherapy response.Journal for immunotherapy of cancer · 2025Article
- Histology-informed microstructural diffusion simulations for MRI cancer characterisation-the Histo-μSim framework.Communications biology · 2025Article
- Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI.Communications medicine · 2025Article
- Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange.Magnetic resonance imaging · 2025Article
- Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025Review
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- Risk Stratification Prediction of Endometrial Cancer Using Microstructural Mapping Based on Time-Dependent Diffusion MRI.Cancer science · 2025Article
- Noninvasive assessment of liver inflammation in metabolic dysfunction associated steatohepatitis using MR cytometry.Npj imaging · 2025Article
- Advanced breast diffusion-weighted imaging: what are the next steps? A proposal from the EUSOBI International Breast Diffusion-weighted Imaging working group.European radiology · 2025Review
- Distinguishing Hepatocellular Carcinoma from Cirrhotic Regenerative Nodules Using MR Cytometry.Cancers · 2025Article
- Enhancing Tumor Microstructural Quantification With Machine Learning and Diffusion-Relaxation MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Joint estimation of compartment-specific TMagnetic resonance in medicine · 2025Article
- From Brownian motion to virtual biopsy: a historical perspective from 40 years of diffusion MRI.Japanese journal of radiology · 2024Review
- Surface Acoustic Wave-Enhanced Multi-View Acoustofluidic Rotation Cytometry (MARC) for Pre-Cytopathological Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multiparametric MRI for characterization of the tumour microenvironment.Nature reviews. Clinical oncology · 2024Review
- Diffusion time dependency of extracellular diffusion.Magnetic resonance in medicine · 2023Article
- Technical Advancements in Abdominal Diffusion-weighted Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe goal of this study is to implement a noninvasive method for in vivo mapping of hepatocyte size. This method will have a broad range of clinical and preclinical applications, as pathological changes in hepatocyte sizes are relevant for the accurate diagnosis and assessments of treatment response of liver diseases.
methodsBuilding on the concepts of temporal diffusion spectroscopy in MRI, a clinically feasible imaging protocol named IMPULSED (Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion) has been developed, which is able to report measurements of cell sizes noninvasively. This protocol acquires a selected set of diffusion imaging data and fits them to a model of water compartments in tissues to derive robust estimates of the cellular structures that restrict free diffusion. Here, we adapt and further develop this approach to measure hepatocyte sizes in vivo. We validated IMPULSED in livers of mice and rats and implemented it to image healthy human subjects using a clinical 3T MRI scanner.
resultsThe IMPULSED-derived mean hepatocyte sizes for rats and mice are about 15-20 µm and agree well with histological findings. Maps of mean hepatocyte size for humans can be achieved in less than 15 minutes, a clinically feasible scan time.
conclusionOur results suggest that this method has potential to overcome major limitations of liver biopsy and provide noninvasive mapping of hepatocyte sizes in clinical applications.
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