ReviewJournal of neuroscience research2021
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
Review in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Systematic review on resting-state fMRI in people with AUD and people who binge drink.Molecular psychiatry · 2025Pooled it
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- Yohimbine as a pharmacological probe for alcohol research: a systematic review of rodent and human studies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- How adolescents' working memory abilities relate to their alcohol craving in real-life contexts depends on biological sex.Drug and alcohol dependence · 2021Trial
- Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Hippocampus-Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults.Hippocampus · 2026Article
- Sex Differences in Scalp-to-Cortex Distance: Implications for Transcranial Magnetic Stimulation Efficacy in Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- The global burden of alcohol-attributable cancers from 1990 to 2021: assessment and projection based on the global burden of disease study 2021.International journal of clinical oncology · 2026Article
- High-intensity and blackout drinking impact on next-day cognitive functioning among college-attending young adults.Alcohol, clinical & experimental research · 2026Article
- Sex differences in blackout: evidence of a relationship between disorders of arousal during sleep and alcohol-related blackout in females.Frontiers in psychology · 2026Review
- Women and alcohol: A call to action.Alcohol, clinical & experimental research · 2026Article
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Greater Neuroimmune System Deficit in Women Than Men With Alcohol Use Disorder.Biological psychiatry · 2026Article
- Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect.Addiction neuroscience · 2025Article
- The alcohol cue-exposure paradigm as a screening tool for alcohol use disorder medication development: A critical review.Alcohol, clinical & experimental research · 2025Review
- Assessing orbitofrontal cortex volume as a predictor of subjective response to alcohol during early adolescence.Alcohol (Fayetteville, N.Y.) · 2025Article
- Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning Among Young Adults: Protocol for a 21-Day Diary Study.JMIR research protocols · 2025Article
- The Neuropathology of Alcohol Use Disorder: Cellular Insights From Human Post-Mortem Studies.Journal of neurochemistry · 2025Review
- Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Among People Who Use Drugs in Turkey.Open forum infectious diseases · 2025Article
- Sex differences in the microglial response to stress and chronic alcohol exposure in mice.Biology of sex differences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Over the last 10 years, rates of alcohol use disorder (AUD) have increased in women by 84% relative to a 35% increase in men. Rates of alcohol use and high-risk drinking have also increased in women by 16% and 58% relative to a 7% and 16% increase in men, respectively, over the last decade. This robust increase in drinking among women highlights the critical need to identify the underlying neural mechanisms that may contribute to problematic alcohol consumption across sex/gender (SG), especially given that many neuroimaging studies are underpowered to detect main or interactive effects of SG on imaging outcomes. This narrative review aims to explore the recent neuroimaging literature on SG differences in brain function and structure as it pertains to alcohol across positron emission tomography, magnetic resonance imaging, and functional magnetic resonance imaging modalities in humans. Additional work using magnetic resonance spectroscopy, diffusion tensor imaging, and event-related potentials to examine SG differences in AUD will be covered. Overall, current research on the neuroimaging of AUD, alcohol consumption, or risk of AUD is limited, and findings are mixed regarding the effect of SG on neurochemical, structural, and functional mechanisms associated with AUD. We address SG disparities in the neuroimaging of AUD and propose a call to action to include women in brain imaging research. Future studies are crucial to our understanding of the neurobiological underpinnings of AUD across neural systems and the vulnerability for AUD among women and men.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.