Evidence map›Paper›PMID 32333380›Full record

ArticleContact dermatitis2020

Hyperkeratotic hand eczema: Eczema or not?

Klaziena Politiek, Laura Loman, Hendri H Pas, Gilles F H Diercks, Henny H Lemmink, Sabrina Z Jan, Peter C van den Akker, Maria C Bolling, Marie L A Schuttelaar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact dermatitis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
  3. Sulfur cream blowing and parching combined with compound ketoconazole creamAmerican journal of translational research · 2024
    Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Klaziena PolitiekDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-6475-6876
Laura LomanDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2731-9284
Hendri H PasDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-8823-2591
Gilles F H DiercksDepartment of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-8053-216X
Henny H LemminkDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-2748-803X
Sabrina Z JanDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-3047-9772
Peter C van den AkkerDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-3734-753X
Maria C BollingDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2086-9363
Marie L A SchuttelaarDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-0766-4382
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperkeratotic hand eczema (HHE) is a typical clinical hand eczema subtype with a largely unknown pathophysiology.

objectiveTo investigate histopathology, expression of keratins (K), epidermal barrier proteins, and adhesion molecules in HHE.

methodsPalmar skin biopsies (lesional and perilesional) were obtained from seven HHE patients and two healthy controls. Moreover, 135 candidate genes associated with palmoplantar keratoderma were screened for mutations.

resultsImmunofluorescence staining showed a significant reduction of K9 and K14 in lesional skin. Upregulation was found for K5, K6, K16, and K17 in lesional skin compared with perilesional and healthy palmar skin. Further, upregulation of involucrin and alternating loricrin staining, both in an extracellular staining pattern, was found. Filaggrin expression was similar in lesional, perilesional, and control skin. No monogenetic mutations were found.

conclusionCurrently, the phenotype of HHE is included in the hand eczema classification system; however, it can be argued whether this is justified. The evident expression of filaggrin and involucrin in lesional skin does not support a pathogenesis of atopic eczema. The upregulation of K6, K16, and K17 and reduction of K9 and K14 might contribute to the underlying pathogenesis. Unfortunately, comparison with hand eczema studies is not possible yet, because similar protein expression studies are lacking.

Indexed as

AdultBiomarkersDermatitis, AtopicFemaleFilaggrin ProteinsHumansHyperkeratosis, EpidermolyticImmunohistochemistryKeratinsMaleUp-RegulationBiomarkersFilaggrin ProteinsFLG protein, humanKeratinseczemahyperkeratotic hand eczemaimmunofluorescence microscopykeratinocyte differentiationpalmar psoriasispathophysiology

Identifiers

PMID32333380
PMCPMC7496397
OpenAlexW3018005092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.