ArticleInternational urology and nephrology2020
Biological basis of lymphocyte ratios for survival prediction in hemodialysis patients: a longitudinal study.
Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The association between platelet-lymphocyte ratio and the risk of all-cause mortality in chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2022Pooled it
- Effect of Clazakizumab on Neutrophil-Lymphocyte Ratio in Patients Receiving Hemodialysis: Secondary Analysis of the POSIBIL6ESKD Phase 2b Trial.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Association of Dynamic Changes in the Neutrophil-to-Lymphocyte Ratio with Mortality in Patients on Maintenance Hemodialysis: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Association of neutrophil-lymphocyte ratio with cardiovascular and all-cause mortality in patients receiving chronic hemodialysis: Systematic review and meta-analysis.World journal of methodology · 2025Article
- The novel CKD-INF score for distinguishing infectious from non-infectious inflammation in patients with non-dialysis chronic kidney disease.Scientific reports · 2025Article
- Neutrophil-to-lymphocyte ratio is associated with sarcopenia risk in overweight maintenance hemodialysis patients.Scientific reports · 2024Article
- Increased thoracic fluid content is associated with higher risk for pneumonia in patients undergoing maintenance hemodialysis.Renal failure · 2023Article
- Combined use of CRP with neutrophil-to-lymphocyte ratio in differentiating between infectious and noninfectious inflammation in hemodialysis patients.Scientific reports · 2023Article
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort.Clinical kidney journal · 2023Article
- High neutrophil-to-lymphocyte ratio is a significant predictor of depressive symptoms in maintenance hemodialysis patients: a cross-sectional study.BMC psychiatry · 2022Article
- Comorbidity burden may explain adiponectin's paradox as a marker of increased mortality risk in hemodialysis patients.Scientific reports · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios have been proposed as emerging markers of inflammation and prognosis in maintenance hemodialysis (MHD) patients. However, to date, no longitudinal performance of these indices is known. The study's purpose was to examine the longitudinal relationship between NLR, PLR, inflammatory and nutritional parameters in MHD patients and how their changes over time associate with adverse clinical outcomes.
methodsA historical longitudinal cohort study was conducted using a clinical database which included 554 patients (mean age, 67.6 ± 14.2 years; 34% women) from a single center receiving MHD from November 2007 to July 2018. NLR, PLR, C-reactive protein (CRP) and nutritional parameters were recorded at 0, 6, 12, 18, 24, 30 and 36 months, followed by 58 additional months of clinical observations.
resultsIn a linear mixed-effects model adjusted for baseline demographics and clinical parameters, including white blood cell count, NLR and PLR were both associated with CRP levels at any given time point observation (linear estimates (95% CI): 1.53, (0.11-2.95) and 1.55 (0.15-2.93), respectively). For each 1.0-unit increase in NLR over time, the fully adjusted all-cause mortality hazard ratio using Cox models with the time-varying risk effect was 1.04 (95% CI 1.01-1.07, P = 0.006). However, when CRP was included in this model, the relationship was no longer significant. PLR's performance did not match the prognostic marker.
conclusionLongitudinal changes in NLR mimic CRP changes and predict all-cause mortality risk in MHD patients.
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