Evidence map›Paper›PMID 32333296›Full record

ArticlePharmacological reports : PR2020

Reduction of the serotonin 5-HT

Marta Baranowska-Kuczko, Hanna Kozłowska, Eberhard Schlicker, Manfred Göthert, Margaret R MacLean, Mirosław Kozłowski, Monika Kloza, Olga Sadowska, Barbara Malinowska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).Naunyn-Schmiedeberg's archives of pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Marta Baranowska-KuczkoDepartment of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz Str. 2A, 15-089, Bialystok, Poland. mabar@umb.edu.pl.
Hanna KozłowskaDepartment of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz Str. 2A, 15-089, Bialystok, Poland.
Eberhard SchlickerDepartment of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.
Manfred GöthertDepartment of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.
Margaret R MacLeanStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Mirosław KozłowskiDepartment of Thoracic Surgery, Medical University of Białystok, Białystok, Poland.
Monika KlozaDepartment of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz Str. 2A, 15-089, Bialystok, Poland.
Olga SadowskaDepartment of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz Str. 2A, 15-089, Bialystok, Poland.
Barbara MalinowskaDepartment of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz Str. 2A, 15-089, Bialystok, Poland.
Medical University of Białystok · PLUniversity of Bonn · DEUniversity of Glasgow · GB

Funding

Uniwersytet Medyczny w Bialymstoku N/ST/ZB/15/002/2213Uniwersytet Medyczny w Bialymstoku N/ST/ZB/16/002/2213
6 · The paper itself

Abstract

backgroundLY393558 is a combined antagonist of serotonin (5-HT) 5-HT

methodsVascular effects of 5-HT receptor agonists, antagonists and a SERT inhibitor were examined in organ bath studies on intralobar hPAs obtained from patients during resection of lung carcinoma.

resultsSerotonin and agonists of the 5-HT

conclusionsLY393558 reduces the 5-HT-induced contraction antagonizing 5-HT

Indexed as

Serotonin 5-HT2 Receptor AntagonistsAgedBenzamidesCitalopramCyclic S-OxidesFemaleHumansMaleMiddle AgedPiperidonesPulmonary ArteryPyridinesReceptor, Serotonin, 5-HT1BReceptor, Serotonin, 5-HT2ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor Antagonists3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamideBenzamidesCitalopramCyclic S-OxidesLY 393558PiperidonesPyridinesReceptor, Serotonin, 5-HT1BReceptor, Serotonin, 5-HT2ASB 22489GSelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AntagonistsSerotonin 5-HT2 Receptor AntagonistsSpiro CompoundsThiadiazines5-HT1B receptor5-HT2A receptorLY393558Pulmonary arterial hypertensionSerotoninSerotonin transporter

Identifiers

PMID32333296
PMCPMC7329800
OpenAlexW3020116996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.