ArticleCurrent microbiology2020
Twin Peaks: Presenting the Antagonistic Molecular Interplay of Curcumin with LasR and LuxR Quorum Sensing Pathways.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Siderophore-producing rhizobacteria improve iron and zinc accumulation in Vigna unguiculata: implications for sustainable nutrition.Die Naturwissenschaften · 2026Article
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- Review
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Inhibitory effect of natural compounds on quorum sensing system inFrontiers in pharmacology · 2024Review
- A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance.Archives of microbiology · 2023Review
- A Comprehensive in vitro and in silico Assessment on Inhibition of CYP51B and Ergosterol Biosynthesis by Eugenol in Rhizopus oryzae.Current microbiology · 2022Article
- Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.Microorganisms · 2022Review
- Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow.Molecular diversity · 2022Article
- Identifying structural-functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation.Molecular diversity · 2022Article
- Recent advances on the regulation of bacterial biofilm formation by herbal medicines.Frontiers in microbiology · 2022Review
- ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish,Frontiers in molecular biosciences · 2022Article
- Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition.Scientific reports · 2021Article
- CRISPR: The Multidrug Resistance Endgame?Molecular biotechnology · 2021Review
- Pinpointing the potential hits for hindering interaction of SARS-CoV-2 S-protein with ACE2 from the pool of antiviral phytochemicals utilizing molecular docking and molecular dynamics (MD) simulations.Journal of molecular graphics & modelling · 2021Article
- Reckoning γ-Glutamyl-S-allylcysteine as a potential main protease (mDrug development and industrial pharmacy · 2021Article
- Prophylactic Treatment of Probiotic and Metformin Mitigates Ethanol-Induced Intestinal Barrier Injury:Mediators of inflammation · 2021Article
- Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity.Pharmaceuticals (Basel, Switzerland) · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing in bacteria is a cell density-dependent phenomenon in which, a community of cells communicate with each other using signalling molecules belonging to various families of which N-acyl homoserine lactone (AHL) is one. AHL acts via ligand-receptor interaction where receptors of AHL differ from species to species, and possess great degree of similarity in conformation at the active site. A macromolecule, LasR, is a receptor protein that binds to N-(3-oxododecanoyl)-L-homoserinelactone (OdDHL), a type of AHL, viz. responsible for biofilm formation in Pseudomonas aeruginosa. Similar macromolecule LuxR, like LasR, found in Vibrio sp. identifies a different AHL, N-(3-oxohexanoyl)-L-homoserine lactone (OhHSL), responsible for the phenomenon of bioluminescence. In silico study depicted that curcumin could bind to both LasR and LuxR by unique sets of hydrogen bonding and hydrophobic interactions that can lead to the inactivation of these proteins, enabling this plant-derived organic AHL antagonist to be categorized as a quorum sensing inhibitor (QSI). To prove this hypothesis, curcumin was treated on P. aeruginosa to access the reduction in biofilm formation and on V. alginolyticus to check its efficacy to reduction in bioluminescence by inhibition of QS. The results of these studies proved curcumin to be an efficient QSI.
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