Observational studyRheumatology (Oxford, England)2020
Association between disease progression and depression onset in persons with radiographic knee osteoarthritis.
Observational study in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of mind-body exercise on knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2024Pooled it
- Economic and Humanistic Burden of Osteoarthritis: An Updated Systematic Review of Large Sample Studies.PharmacoEconomics · 2023Pooled it
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Pragmatic evaluation of prescription glucosamine sulfate (pGS) in knee osteoarthritis: insights from a Filipino cohort.Frontiers in medicine · 2026Article
- High prevalence of depression in symptomatic knee osteoarthritis: a cross-sectional study on risk factors and therapeutic implications.BMC musculoskeletal disorders · 2025Observational
- Osteoarthritis: Mechanisms and Therapeutic Advances.MedComm · 2025Review
- Depressive Symptoms and Osteoporosis in Middle-Aged and Older Adults: A Cross-Sectional Analysis of NHANES and HRS Data.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988-1994 and 1999-2018.Aging medicine (Milton (N.S.W)) · 2024Article
- Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis.Arthritis care & research · 2024Article
- Time-varying treatment effect modification of oral analgesic effectiveness by depressive symptoms in knee osteoarthritis: an application of structural nested mean models in a prospective cohort.International journal of epidemiology · 2024Article
- Sarcopenia predicts immune-related adverse events due to anti-PD-1/PD-L1 therapy in patients with advanced lung cancer.Frontiers in oncology · 2024Article
- Sarcopenia is an independent risk factor for depression in patients with advanced lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Momentary Associations of Osteoarthritis Pain and Affect: Depression as Moderator.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort.BMC musculoskeletal disorders · 2022Article
- Depression in Osteoarthritis: Current Understanding.Neuropsychiatric disease and treatment · 2022Review
- Non-invasive brain stimulation for osteoarthritis.Frontiers in aging neuroscience · 2022Review
- Tibial condylar valgus osteotomy for the treatment of intra-articular varus deformity of the knee.Annals of joint · 2022Review
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesOsteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA.
methodsOsteoarthritis Initiative participants (n = 1651) with radiographic disease (Kellgren-Lawrence grade ≥2) in one or both knees and below the screening threshold for probable depression [Center for Epidemiological Studies Depression (CES-D) scale <16] at baseline were included. Disease severity was measured from baseline to the third annual follow-up visit using joint space width, 20-meter gait speed, and the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale, each categorized into quintiles. Depression onset (CES-D ≥ 16) was assessed annually at four follow-up visits. Marginal structural models that account for time-dependent confounding and attrition evaluated the association between each time-varying disease severity measure and depression onset.
resultsEach disease severity measure exhibited a non-linear relationship concerning the probability of depression onset, with the higher quintiles generally being associated with a larger risk. The highest quintile (relative to the lowest) of joint space width and gait speed were both significantly associated with depression onset. By contrast, none of the higher pain quintiles compared with the lowest were significantly associated with the onset of depression.
conclusionFaster disease progression as measured by either worsening structural severity or decreasing physical performance corresponds to an increased risk of depression among individuals with radiographic knee OA.
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