ArticleCell death & disease2020
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57
Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.
- Role of m5C methylation in digestive system tumors (Review).Molecular medicine reports · 2025Pooled it
- Multimodal Imaging under Artificial Intelligence Algorithm for the Diagnosis of Liver Cancer and Its Relationship with Expressions of EZH2 and p57.Computational intelligence and neuroscience · 2022Trial
- NSUN2-FOSB reciprocity facilitates leukemogenesis in an mHaematologica · 2026Article
- NSUN2 regulates PARP9 progression through m5C modification to mediate breast cancer progression.Cell division · 2026Article
- YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA.Cancer science · 2026Article
- Downregulated m⁵C regulator NSUN6 enhances proliferation, migration and affects immune regulation in ovarian cancer.Scientific reports · 2026Article
- mBiology direct · 2026Review
- NSUN2 promoted tumor growth and metastatic via mCell death & disease · 2026Article
- AI-driven virtual screening platform identifies novel NSUN2 inhibitor candidates for targeted cancer therapy: a computational drug discovery approach.NPJ precision oncology · 2026Article
- ULSL: Unified Latent and Similarity Learning for robust multi-omics cancer subtype identification.Bioinformatics advances · 2026Article
- NSUN3 promotes oral squamous cell carcinoma progression through autophagy activation and FOXO pathway modulation.Frontiers in oncology · 2026Article
- m5C and m6A cooperatively stabilize EPHB4 to drive lymphatic metastasis in gastric cancer.Frontiers in genetics · 2026Article
- NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?Cell death & disease · 2025Review
- NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.Cancers · 2025Article
- tRNA modifications: greasing the wheels of translation and beyond.RNA biology · 2025Review
- m5C-Related Regulators Define Tumor Microenvironment and Predict Prognosis in Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- NSUN7-mediated mJournal of translational medicine · 2025Article
- RNA m5C methylation in cancer: mechanisms and biological impact.Oncogenesis · 2025Review
- RNA chemistry and therapeutics.Nature reviews. Drug discovery · 2025Review
- Dynamic landscape and regulation of mScience China. Life sciences · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.