SynthesisBMJ open respiratory research2020
Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence.
Synthesis in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Effectiveness of Topiramate Versus Acetazolamide in the Management of Idiopathic Intracranial Hypertension: ASystematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Pooled it
- Pharmacological treatment for central sleep apnoea in adults.The Cochrane database of systematic reviews · 2023Pooled it
- The role of acetazolamide in sleep apnea at sea level: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Pooled it
- Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis.Chest · 2020Pooled it
- Acetazolamide to prevent ventilatory drive withdrawal in REM sleep apnoea: a randomised controlled trial.Thorax · 2026Trial
- ADA-HF: acetazolamide as a chloride sparing diuretic in patients admitted to hospital with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Trial
- Prochlorperazine maleate versus placebo for the prophylaxis of acute mountain sickness: a double-blind randomized controlled trial.Journal of travel medicine · 2025Trial
- Trial
- Probiotic supplementation preserves oxygen saturation during severe hypobaric hypoxia in lowland and high-altitude populations.iScience · 2026Article
- The efficacy and safety of oral and topical carbonic anhydrase inhibitors for the treatment of macular edema secondary to retinitis pigmentosa: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Reduction of Cerebrospinal Fluid Leaks in Idiopathic Intracranial Hypertension with Glucagon-like Peptide-1 Receptor Agonist Use.Journal of neurological surgery. Part B, Skull base · 2026Article
- Acclimatization Effects ofInternational journal of molecular sciences · 2026Article
- Ιdiosyncratic Non-Cardiogenic Pulmonary Edema Following Acetazolamide Administration: A Case Report and Review of Pathogenic Mechanisms.Reports (MDPI) · 2026Article
- Oral Administration of a Bivalent Carbonic Anhydrase IX Near-Infrared Imaging Agent Detects Hypoxic Tumors in a Mouse Model.ACS sensors · 2026Article
- Exogenous ketone monoester supplementation: a potential alternative strategy to mitigate altitude sickness?European journal of applied physiology · 2026Review
- Non-positive Airway Pressure Therapies for Obstructive Sleep Apnoea and Central Sleep Apnoea.Cardiac failure review · 2026Review
- Hypokalemic Periodic Paralysis Associated With a RareCase reports in genetics · 2026Article
- Drug therapy for obstructive sleep apnoea: promises and challenges.Lancet (London, England) · 2025Article
- Benefits and challenges of multi-delay arterial spin labeling in clinical practice: measuring perfusion and cerebrovascular reactivity in intracranial steno-occlusive disease.Insights into imaging · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
introductionAcetazolamide (AZM) is used for various conditions (eg, altitude sickness, sleep apnoea, glaucoma), but therapy is often limited by its side effect profile. Our objective was to estimate the risk of commonly reported side effects based on meta-analyses. We hypothesised that these risks are dose-dependent.
methodsWe queried MEDLINE/EMBASE (Medical Literature Analysis and Retrieval System Online/Excerpta Medica dataBASE) up until 04/10/2019, including any randomised placebo-controlled trial in which adults received oral AZM versus placebo reporting side effects. Eligibility assessment was performed by two independent reviewers. Data were abstracted by one reviewer who verified key entries at a second time point. For side effects reported by
resultsWe included 42 studies in the meta-analyses (N DISCUSSION: This comprehensive meta-analysis of low-to-moderate quality evidence defines risk of common AZM side effects and corroborates dose dependence of some side effects. These results may inform clinical decision making and support efforts to establish the lowest effective dose of AZM for various conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.