ArticleAcademic radiology2021
Poroelastic Mechanical Properties of the Brain Tissue of Normal Pressure Hydrocephalus Patients During Lumbar Drain Treatment Using Intrinsic Actuation MR Elastography.
Article in Academic radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Cerebral blood flow, autoregulation and vascular reactivity in normal pressure hydrocephalus: a systematic review.Fluids and barriers of the CNS · 2025Pooled it
- Applications of elastography in operative neurosurgery: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022Pooled it
- Evaluating the Performance and Repeatability of Poroelastic and Poroviscoelastic Models in Intrinsic MR Elastography.NMR in biomedicine · 2025Article
- Article
- Biomechanical instability of the brain-CSF interface in hydrocephalus.Brain : a journal of neurology · 2024Review
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Viscoelastic polyacrylamide MR elastography phantoms with tunable damping ratio independent of shear stiffness.Journal of the mechanical behavior of biomedical materials · 2024Article
- Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness.Scientific reports · 2024Article
- Cortical matrix remodeling as a hallmark of relapsing-remitting neuroinflammation in MR elastography and quantitative MRI.Acta neuropathologica · 2024Article
- Can magnetic resonance elastography serve as a diagnostic tool for gradual-onset brain disorders?Neurosurgical review · 2023Article
- Transversely-isotropic brain in vivo MR elastography with anisotropic damping.Journal of the mechanical behavior of biomedical materials · 2023Article
- Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves.Magnetic resonance in medicine · 2023Article
- Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.Medical image analysis · 2022Article
- Magnetic resonance elastography in normal pressure hydrocephalus-a scoping review.Neurosurgical review · 2022Article
- 3D amplified MRI (aMRI).Magnetic resonance in medicine · 2021Article
- Lorentz force induced shear waves for magnetic resonance elastography applications.Scientific reports · 2021Article
- Review
- Beyond pressure: intracranial compliance and retinal biomarkers in idiopathic normal pressure hydrocephalus.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesHydrocephalus (HC) is caused by accumulating cerebrospinal fluid resulting in enlarged ventricles and neurological symptoms. HC can be treated via a shunt in a subset of patients; identifying which individuals will respond through noninvasive imaging would avoid complications from unsuccessful treatments. This preliminary work is a longitudinal study applying MR Elastography (MRE) to HC patients with a focus on normal pressure hydrocephalus (NPH). MATERIALS AND
methodsTwenty-two ventriculomegaly patients were imaged and subsequently received a lumbar drain placement for cerebrospinal fluid (CSF) drainage. NPH lumbar drain responders and NPH syndrome nonresponders were categorized by clinical presentation. Displacement images were acquired using intrinsic activation (IA) MRE and poroelastic inversion recovered shear stiffness and hydraulic conductivity values. A stable IA-MRE inversion protocol was developed to produce unique solutions for both recovered properties, independent of initial estimates.
resultsProperty images showed significantly increased shear modulus (p = 0.003 in periventricular region, p = 0.005 in remaining cerebral tissue) and hydraulic conductivity (p = 0.04 in periventricular region) in ventriculomegaly patients compared to healthy volunteers. Baseline MRE imaging did not detect significant differences between NPH lumbar drain responders and NPH syndrome nonresponders; however, MRE time series analysis demonstrated consistent trends in average poroelastic shear modulus values over the course of the lumbar drain process in responders (initial increase, followed by a later decrease) which did not occur in nonresponders.
conclusionThese findings are indicative of acute mechanical changes in the brain resulting from CSF drainage in NPH patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.