Evidence map›Paper›PMID 32331955›Full record

SynthesisThe American journal of emergency medicine2021

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis.

Anwar Santoso, Raymond Pranata, Arief Wibowo, Makhyan Jibril Al-Farabi, Ian Huang, Budhi Antariksa

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 19 syntheses or guidelines pooled it.

  1. Are Pre-Hospitalization ECG Abnormalities Associated With Increased Mortality in COVID-19 Patients? A Quantitative Systematic Literature Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Pooled it
  2. Pooled it
  3. COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Prevalence of abnormal cardiovascular magnetic resonance findings in recovered patients from COVID-19: a systematic review and meta-analysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020
    Pooled it
  16. Pooled it
  17. COVID-19 and the Heart: A Systematic Review of Cardiac Autopsies.Frontiers in cardiovascular medicine · 2020
    Pooled it
  18. Pooled it
  19. Pooled it
  20. Observational

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Anwar SantosoDepartment of Cardiology - Vascular Medicine, Universitas Indonesia, Harapan Kita Hospital - National Cardiovascular Centre, Jalan Letjen S. Parman kav 87, Jakarta 11420, Indonesia. Electronic address: anwarsantoso@inaheart.org.
Raymond PranataFaculty of Medicine, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Tangerang 15811, Indonesia.
Arief WibowoDepartment of Cardiology - Vascular Medicine, Padjadjaran University, Dr. Hasan Sadikin Hospital, Jalan Pasteur No: 38, Bandung 40161, Indonesia.
Makhyan Jibril Al-FarabiDepartment of Cardiology - Vascular Medicine, Airlangga University, Soetomo Academic and General Hospital, Jalan Mayjen Moestopo No: 6-8, Surabaya 60286, Indonesia. Electronic address: m.farabi.17@ucl.ac.uk.
Ian HuangFaculty of Medicine, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Tangerang 15811, Indonesia.
Budhi AntariksaDepartment of Pulmonology and Respiratory Medicine, Universitas Indonesia, Persahabatan Hospital, Jalan Persahabatan Raya No: 1, Jakarta 13230, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. Methods: We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. Results: There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], Conclusion: Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.

Indexed as

AdultCOVID-19Critical IllnessHeart DiseasesHumansIntensive Care UnitsRisk FactorsCardiac injuryCoronavirusCOVID-19MortalityTroponin

Identifiers

PMID32331955
PMCPMC7166308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.