Evidence map›Paper›PMID 32331824›Full record

ArticleBiological psychiatry2020

Acetylcholine Muscarinic M

Leigh C Walker, Alice E Berizzi, Nicola A Chen, Patricia Rueda, Victoria M Perreau, Katherine Huckstep, Jirawoot Srisontiyakul, Piyarat Govitrapong, Jia Xiaojian, Craig W Lindsley and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. The 5-HTPharmacology research & perspectives · 2021
    Trial
  3. MDMA alters fear extinction, and reduces alcohol consumption in inbred alcohol preferring iP rats but not outbred Wistar rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. [Pharmacological reports : PR · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Biological psychiatry global open science · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Leigh C WalkerFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Alice E BerizziDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Nicola A ChenFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Patricia RuedaDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Victoria M PerreauFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Katherine HuckstepFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Jirawoot SrisontiyakulResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Piyarat GovitrapongResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Jia XiaojianShenzhen Kangning Hospital, Shenzhen University Health Science Center, Shenzhen, China; Shenzhen Mental Health Center, Shenzhen University Health Science Center, Shenzhen, China.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee; Department of Chemistry, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee.
Carrie K JonesDepartment of Pharmacology, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee; Department of Chemistry, Vanderbilt Center for Neuroscience and Drug Discovery, Vanderbilt University, Nashville, Tennessee.
Darren M RiddyDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Arthur ChristopoulosDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Christopher J LangmeadDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: chris.langmead@monash.edu.
Andrew J LawrenceFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia. Electronic address: andrew.lawrence@florey.edu.au.
The University of Melbourne · AUMonash University · AUMahidol University · THVanderbilt University · USDiscovery Institute · USShenzhen KangNing Hospital · CN

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

backgroundAlcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and seeking alters frontostriatal function.

methodsWe performed genome-wide RNA sequencing and subsequent quantitative polymerase chain reaction and receptor binding validation in the caudate-putamen of human AUD samples to identify potential therapeutic targets. We then back-translated our top candidate targets into a rodent model of long-term alcohol consumption to assess concordance of molecular adaptations in the rat striatum. Finally, we adopted rat behavioral models of alcohol intake and seeking to validate a potential therapeutic target.

resultsWe found that G protein-coupled receptors were the top canonical pathway differentially regulated in individuals with AUD. The M

conclusionsCollectively, these results identify the M

Indexed as

AlcoholismReceptor, Muscarinic M4AcetylcholineAnimalsCholinergic AgentsHumansRatsRodentiaAcetylcholineCholinergic AgentsReceptor, Muscarinic M4AcetylcholineAlcoholCaudate-putamenDorsal striatumMuscarinicRelapse

Identifiers

PMID32331824
PMCPMC11390032
OpenAlexW3008237259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.