Observational studyPsychosomatics
Depression and Inflammation in Patients With Lung Cancer: A Comparative Analysis of Acute Phase Reactant Inflammatory Markers.
Observational study in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Article
- Article
- Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients.The Kaohsiung journal of medical sciences · 2026Article
- Predictive features analysis and nomogram construction for predicting depression in elderly patients.Frontiers in psychology · 2025Article
- Evaluating the Prognostic Nutritional Index for Predicting the Clinical Relevance of Angiographically Intermediate Coronary Lesions.Anatolian journal of cardiology · 2024Article
- The Impact of a Diet Rich in Omega-3 Fatty Acids on the Quality of Life of Patients with Squamous Cell Lung Cancer and Comorbid Depression: A Retrospective Study.Actas espanolas de psiquiatria · 2024Article
- Phenotypic distinctions in depression and anxiety: a comparative analysis of comorbid and isolated cases.Psychological medicine · 2023Article
- The Role of Procalcitonin/Albumin Ratio and CRP/Albumin Ratio in Predicting In-hospital Mortality in COVID-19 Patients.Journal of acute medicine · 2023Article
- Inflammation Assessed by Latent Profiling is Associated with Stress and Suicidality but not Depression: Findings from the RADAR Cohort Study.Annals of LGBTQ public and population health · 2023Article
- Molecular clustering based on gene set expression and its relationship with prognosis in patients with lung adenocarcinoma.Journal of thoracic disease · 2022Article
- Potential use of albumin and neutrophil-to-lymphocyte ratio to guide the evaluation and treatment of cancer-related depression and anxiety.Psycho-oncology · 2022Article
- Application of Narrative Nursing Combined With Focused Solution Model to Anxiety and Depression in Patients With Lung Tumor During Perioperative Period.Frontiers in surgery · 2022Article
- The relationship between Comprehensive Geriatric Assessment parameters and depression in elderly patients.Frontiers in aging neuroscience · 2022Article
- Prognostic implications of depression and inflammation in patients with metastatic lung cancer.Future oncology (London, England) · 2021Article
- C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia.Psychiatry investigation · 2020Article
- Neutrophil to Lymphocyte Ratio in Lung Cancer: Implications for Depressive Symptoms and Survival.Clinical oncology and research · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDepression and inflammation are intertwined, which is particularly relevant for patients with lung cancer who have an abundance of inflammation and experience depression. Acute phase reactants (APRs), albumin and C-reactive protein (CRP), are easily interpretable indirect markers of inflammation that have never been concomitantly compared with depression. Inflammation increases CRP (positive APR) and decreases albumin (negative APR). We hypothesize that albumin will be similarly associated with depression, thereby helping to inform the diagnosis of inflammatory depression.
objectiveCompares the relationship between depression and representative positive and negative acute phase reactants in patients with metastatic lung cancer.
methodsPatients (n = 109) with metastatic lung cancer were evaluated for depression using the Hospital Anxiety and Depression Scale. Inflammation as measured by positive (CRP) and negative (albumin) APRs along with demographic and treatment variables were analyzed for associations with depression.
resultsDepression was associated with lower albumin (r = -0.35, P < 0.001), higher CRP (r = 0.47, P < 0.001), and the CRP/albumin ratio (r = 0.45, P < 0.001). Hierarchical linear regression modeling found that albumin was associated with depression when controlling for demographics, disease, and treatment types (β = -0.28, P = 0.01). When both APRs were in the model, only CRP predicted depression (β = 0.31, P = 0.01), and albumin did not moderate CRP and depression. CRP/albumin ratio did not add to understanding depression variability, but patients with both low albumin and high CRP had particularly severe depression.
conclusionAlbumin is associated with depression but not to a greater extent than CRP. The coupling of lower albumin and higher CRP describes more severe depression. Positive and negative APRs may form a distinct biologic signature to help identify patients with inflammatory depression in the lung cancer setting.
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