Evidence map›Paper›PMID 32331569›Full record

ArticleThe Journal of investigative dermatology2020

A Spectrum of Skin Disease: How Staphylococcus aureus Colonization, Barrier Dysfunction, and Cytokines Shape the Skin.

Mary C Moran, Lisa A Beck, Christopher T Richardson

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mary C MoranDepartment of Dermatology, University of Rochester Medical Center, Rochester, New York, USA; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA. Electronic address: Mary_Moran@URMC.Rochester.edu.
Lisa A BeckDepartment of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.
Christopher T RichardsonDepartment of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.
University of Rochester Medical Center · US

Funding

Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GEHA, RAIF SALIM · 2015 to 2019
$30.6M
Biomarker Identification, Viral Susceptibility and Management in S. aureus Colonized AD PatientsU01AI152011 · NIAID · UNIVERSITY OF ROCHESTER · PI Lisa Ann Beck · 2020 to 2026
$3.2M
Infection and Immunity: The Pathogenesis of Host-Microbe InteractionsT32AI118689 · NIAID · UNIVERSITY OF ROCHESTER · PI Paul M. Dunman, BRIAN M WARD · 2015 to 2026
$2.5M
NIAID NIH HHS T32 AI118689NIAID NIH HHS U01 AI152011NIAID NIH HHS U19 AI117673
6 · The paper itself

Abstract

Cytokines are key mediators of skin homeostasis and disease through their effects on keratinocytes, skin barrier integrity, immune activation, and microbial ecology. Sirobhushanam et al. (2020) suggest that the IFN signature in lupus erythematosus (LE) alters expression of epithelial barrier and adhesin genes, which, in turn, promotes Staphylococcus aureus colonization. This work highlights the need to better understand both barrier function and S. aureus colonization in LE, two new potential therapeutic targets for the treatment of LE.

Indexed as

Dermatitis, AtopicStaphylococcal InfectionsCytokinesHumansSkinStaphylococcus aureusCytokines

Identifiers

PMID32331569
PMCPMC7384433
OpenAlexW3020606009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.