Evidence map›Paper›PMID 32331458›Full record

ArticleMolecules (Basel, Switzerland)2020

Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers.

Tatiana S Demina, Maria G Drozdova, Chantal Sevrin, Philippe Compère, Tatiana A Akopova, Elena Markvicheva, Christian Grandfils

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tatiana S DeminaEnikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya str., 117393 Moscow, Russia.ORCID 0000-0003-0271-2231
Maria G DrozdovaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.
Chantal SevrinInterfaculty Research Centre on Biomaterials (CEIB), University of Liège, Chemistry Institute, B6C, 11 Allée du 6 août, B-4000 Liege (Sart-Tilman), Belgium.
Philippe CompèreInterfaculty Research Centre on Biomaterials (CEIB), University of Liège, Chemistry Institute, B6C, 11 Allée du 6 août, B-4000 Liege (Sart-Tilman), Belgium.ORCID 0000-0003-3619-4997
Tatiana A AkopovaEnikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya str., 117393 Moscow, Russia.
Elena MarkvichevaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.
Christian GrandfilsInterfaculty Research Centre on Biomaterials (CEIB), University of Liège, Chemistry Institute, B6C, 11 Allée du 6 août, B-4000 Liege (Sart-Tilman), Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-stabilizing biodegradable microcarriers were produced via an oil/water solvent evaporation technique using amphiphilic chitosan-g-polyester copolymers as a core material in oil phase without the addition of any emulsifier in aqueous phase. The total yield of the copolymer-based microparticles reached up to 79 wt. %, which is comparable to a yield achievable using traditional emulsifiers. The kinetics of microparticle self-stabilization, monitored during their process, were correlated to the migration of hydrophilic copolymer's moieties to the oil/water interface. With a favorable surface/volume ratio and the presence of bioadhesive natural fragments anchored to their surface, the performance of these novel microcarriers has been highlighted by evaluating cell morphology and proliferation within a week of cell cultivation in vitro.

Indexed as

MicrospheresBiocompatible MaterialsChitosanFibroblastsPolyestersPolymersTissue EngineeringBiocompatible MaterialsChitosanPolyestersPolymerschitosanfibroblastsgraft-copolymersmicrocarriersoil/water emulsionpolylactidetissue engineering

Identifiers

PMID32331458
PMCPMC7221781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.