ReviewInternational journal of molecular sciences2020
Kisspeptin and Testicular Function-Is it Necessary?
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.Journal of assisted reproduction and genetics · 2025Article
- Reproductive integration of leptin and kisspeptin in small ruminants: Mechanisms, biomarker potential, and prospects for precision breeding.Veterinary world · 2025Review
- Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner.Reproductive biology and endocrinology : RB&E · 2025Article
- Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.Cell biochemistry and biophysics · 2025Review
- Association of Kisspeptin and KISSReproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Impact of Ultraviolet C Radiation on Male Fertility in Rats: Suppression of Autophagy, Stimulation of Gonadotropin-Inhibiting Hormone, and Alteration of miRNAs.International journal of molecular sciences · 2025Article
- Prolonged post-androgen abuse hypogonadism: potential mechanisms and a proposed standardized diagnosis.Frontiers in endocrinology · 2025Review
- IGF-1 Acts through Kiss1-expressing Cells to Influence Metabolism and Reproduction.bioRxiv : the preprint server for biology · 2024Article
- Article
- Kisspeptin treatment reverses high prolactin levels and improves gonadal function in hypothyroid male rats.Scientific reports · 2023Article
- The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproductionFrontiers in endocrinology · 2023Article
- Impact of stress on male fertility: role of gonadotropin inhibitory hormone.Frontiers in endocrinology · 2023Review
- Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt's voles (Lasiopodomys brandtii).Microbiome · 2022Article
- An Alkaloid from a Highly Invasive Seaweed Increases the Voracity and Reproductive Output of a Model Fish Species.Marine drugs · 2022Article
- Effects of kisspeptin incubation on the mature mouse testicular sperms quality: An experimental study.International journal of reproductive biomedicine · 2022Article
- Same total normal forms sperm counts of males from Lhasa and Shanghai, China.Environmental science and pollution research international · 2022Article
- Article
- Effect of Kisspeptin-54 on Testicular Degeneration Induced by Cadmium Chloride.Archives of Razi Institute · 2022Article
- The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.Frontiers in endocrinology · 2022Review
- The role of Kisspeptin signaling in Oocyte maturation.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.