ArticleJournal of clinical medicine2020
Iron Deficiency: Impact on Functional Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07053475 (IRONICA), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
IRONICA: IRON Repletion in Congestive Heart Failure - A Randomized Controlled Trial Comparing Oral Versus IV Approaches
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Markers of Iron Metabolism and Outcomes in Patients with Heart Failure: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Intravenous ferric carboxymaltose and exercise capacity in iron-deficient kidney transplant recipients: a randomised, placebo-controlled trial in the Netherlands.EClinicalMedicine · 2026Article
- Prevalence and Clinical Correlates of Iron Deficiency in Vietnamese Patients with Chronic Heart Failure.Biomedicines · 2026Article
- Iron Balance and Cardiovascular Health: The Double-Edged Role of Deficiency and Overload.Cardiovascular toxicology · 2026Review
- Impact of iron deficiency on left ventricular noninvasive myocardial work indices in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation.Cardiology journal · 2026Article
- Impact of iron deficiency on health-related quality of life and functional status in adults with chronic heart failure in Nigeria.BMC cardiovascular disorders · 2025Article
- Serum soluble transferrin receptor (sTfR) in HFpEF: associations with cardiac function and exercise tolerance.European journal of medical research · 2025Article
- Benefits of intravenous iron supplementation in heart failure.Global cardiology science & practice · 2024Article
- Relationship between serum iron level and physical function in heart failure patients is lost by presence of diabetes.ESC heart failure · 2024Article
- Anemia and Iron Deficiency Predict All-Cause Mortality in Patients with Heart Failure and Preserved Ejection Fraction: 6-Year Follow-Up Study.Diagnostics (Basel, Switzerland) · 2024Article
- Heart Failure With Preserved Ejection Fraction With CKD: A Narrative Review of a Multispecialty Disorder.Kidney medicine · 2023Review
- Iron Deficiency in Heart Failure: A Korea-Oriented Review.International journal of heart failure · 2023Review
- A review of the impact, pathophysiology, and management of atrial fibrillation in patients with heart failure with preserved ejection fraction.American heart journal plus : cardiology research and practice · 2023Review
- Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients.Journal of personalized medicine · 2023Article
- Treatment of Iron Deficiency in Heart Failure.Current cardiology reports · 2023Review
- Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients.ESC heart failure · 2023Observational
- Article
- Cardiovascular and metabolic determinants of quality of life in patients with cancer.ESC heart failure · 2023Article
- How to diagnose iron deficiency in chronic disease: A review of current methods and potential marker for the outcome.European journal of medical research · 2023Review
- Iron Deficiency and Deranged Myocardial Energetics in Heart Failure.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of iron deficiency (ID) have been widely studied in heart failure (HF) with reduced ejection fraction. On the other hand, studies in HF with preserved ejection fraction (HFpEF) are few and have included small numbers of participants. The aim of this study was to assess the role that ID plays in functional capacity and quality of life (QoL) in HFpEF while comparing several iron-related biomarkers to be used as potential predictors. ID was defined as ferritin <100 ng/mL or transferrin saturation <20%. Submaximal exercise capacity, measured by the 6-min walking test (6MWT), and QoL, assessed by the Minnesotta Living with Heart Failure Questionnaire (MLHFQ), were compared between iron deficient patients and patients with normal iron status. A total of 447 HFpEF patients were included in the present cross-sectional study, and ID prevalence was 73%. Patients with ID performed worse in the 6MWT compared to patients with normal iron status (ID 271 ± 94 m vs. non-ID 310 ± 108 m,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.