Evidence map›Paper›PMID 32331315›Full record

ArticleNutrients2020

Maternal Allergy and the Presence of Nonhuman Proteinaceous Molecules in Human Milk.

Pieter M Dekker, Sjef Boeren, Alet H Wijga, Gerard H Koppelman, Jacques J M Vervoort, Kasper A Hettinga

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. The evolution of nutritional care in children with food allergies - With a focus on cow's milk allergy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pieter M DekkerFood Quality and Design Group, Wageningen University & Research, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands.ORCID 0000-0002-0189-3213
Sjef BoerenLaboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.ORCID 0000-0002-0847-8821
Alet H WijgaNational Institute of Public Health and the Environment-Centre for Prevention and Health Services Research, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Gerard H KoppelmanBeatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8567-3252
Jacques J M VervoortLaboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.
Kasper A HettingaFood Quality and Design Group, Wageningen University & Research, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands.ORCID 0000-0002-9017-4447
Wageningen University & Research · NLNational Institute for Public Health and the Environment · NLUniversity Medical Center Groningen · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 15299
6 · The paper itself

Abstract

Human milk contains proteins and/or protein fragments that originate from nonhuman organisms. These proteinaceous molecules, of which the secretion might be related to the mother's allergy status, could be involved in the development of the immune system of the infant. This may lead, for example, to sensitization or the induction of allergen-specific tolerance. The aim of this study was to investigate the relation between maternal allergy and the levels of nonhuman proteinaceous molecules in their milk. In this study, we analysed trypsin-digested human milk serum proteins of 10 allergic mothers and 10 nonallergic mothers. A search was carried out to identify peptide sequences originating from bovine or other allergenic proteins. Several methods were applied to confirm the identification of these sequences, and the differences between both groups were investigated. Out of the 78 identified nonhuman peptide sequences, 62 sequences matched

Indexed as

Breast FeedingMothersAllergensAnimalsCattleFemaleFood HypersensitivityHumansInfantLactoglobulinsMilkMilk, HumanMilk HypersensitivityAllergensLactoglobulinsallergen transferhuman milkmaternal allergynonhuman proteinsβ-lactoglobulin

Identifiers

PMID32331315
PMCPMC7230597
OpenAlexW3019289600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.