ArticlePregnancy hypertension2020
Relative impact of pre-eclampsia on birth weight in a low resource setting: A prospective cohort study.
Article in Pregnancy hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis.PLoS medicine · 2025Pooled it
- Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes.Biological trace element research · 2025Pooled it
- Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.The Lancet. Global health · 2025Trial
- Causal Effects of Common Pregnancy Complications on Neonatal Birth Weight: A Mendelian Randomization Study.International journal of women's health · 2026Article
- Adverse Materno-Foetal Outcomes of Pre-Eclampsia at a Rural Tertiary Hospital in the Eastern Cape Province of South Africa.International journal of environmental research and public health · 2025Article
- Postpartum Cardiovascular Health in African Women Following Pre-Eclampsia: A Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Risk factors associated with progression from pre-eclampsia to eclampsia: A prospective cohort study and population-wide data analysis.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Variations in emergency care for severe pre-eclampsia in Uganda: a national evaluation study.AJOG global reports · 2025Article
- The association between gestational hypothyroidism in pregnant women with preeclampsia, maternal liver function indicators, and neonatal birth weight: a study in Chinese pregnant women.Frontiers in endocrinology · 2025Article
- Preeclampsia, prevalence and associated factors.PloS one · 2025Article
- Implementing telemedicine for the care of women with gestational diabetes mellitus in a rural hospital: an observational retrospective study.BMC health services research · 2024Observational
- Decreased vascular reactivity associated with increased IL-8 in 6-month-old infants of mothers with pre-eclampsia.Pediatric research · 2024Article
- Implementation challenges in preeclampsia care: perspectives from health care professionals in urban Uganda.AJOG global reports · 2024Article
- Article
- Pre-eclampsia among Pregnant Women Admitted to the Department of Obstetrics and Gynaecology of a Tertiary Care Centre.JNMA; journal of the Nepal Medical Association · 2023Article
- Plasma eNOS Concentration in Healthy Pregnancy and in Hypertensive Disorders of Pregnancy: Evidence of Reduced Concentrations in Pre-Eclampsia from Two Independent Studies.Diseases (Basel, Switzerland) · 2023Article
- Prevalence and immediate outcomes of low birth weight neonates born of pre-eclamptic women at Moi Teaching and Referral Hospital, Kenya.The Pan African medical journal · 2023Article
- Influence of gestational weight gain on baby's birth weight in Addis Ababa, Central Ethiopia: a follow-up study.BMJ open · 2022Article
- Preventing death following unsafe abortion: a case series from urban Uganda.AJOG global reports · 2022Article
- The association of hypertensive disorders of pregnancy with small for gestational age and intertwin birthweight discordance.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesLow birth-weight is a major risk factor for perinatal death in sub-Saharan Africa, but the relative contribution of determinants of birth-weight are difficult to disentangle in low resource settings. We sought to delineate the relationship between birth-weight and maternal pre-eclampsia across gestation in a low-resource obstetric setting. STUDY
designProspective cohort study in a tertiary referral centre in urban Uganda, including 971 pre-eclampsia cases and 1461 control pregnancies between 28 and 42 weeks gestation.
main outcome measuresNonlinear modeling of birth-weight versus maternal pre-eclampsia status across gestation. Models were adjusted for maternal-fetal characteristics including maternal age, parity, HIV status, and socio-economic status. Propensity score matching was used to control for the severity of pre-eclampsia at different gestational ages.
resultsMean birth-weight for pre-eclampsia cases was 2.48 kg (±0.81SD) compared to 3.06 kg (±0.46SD) for controls (p < 0.001). At 28 weeks, the mean birth-weight difference between pre-eclampsia cases and controls was 0.58 kg (p < 0.05), narrowing to 0.17 kg at 39 weeks (p < 0.01). Controlling for pre-eclampsia severity only partially explained this gestational difference in mean birth-weight between pre-eclampsia cases and controls. Holding gestational age constant, pre-eclampsia status predicted 7.1-10.5% of total variation in birth-weight, compared to 0.05-0.7% for all other maternal-fetal characteristics combined.
conclusionsPre-eclampsia is the dominant predictor of birth-weight in low-resource settings and hence likely to heavily influence perinatal survival. The impact of pre-eclampsia on birth-weight is smaller with advancing gestational age, a difference that is not fully explained by controlling for pre-eclampsia severity.
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