Evidence map›Paper›PMID 32330734›Full record

ReviewAdvances in colloid and interface science2020

Biodegradable calcium phosphate nanoparticles for cancer therapy.

Razieh Khalifehzadeh, Hamed Arami

Open access · greenAbstract readReview
In one paragraph

Review in Advances in colloid and interface science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 162 citations in OpenAlex.

  1. Article
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  10. Next Generation Calcium Nanomaterials: Disrupting Tumor CaInternational journal of nanomedicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Razieh KhalifehzadehDepartment of Chemical Engineering, Stanford University, Shriram Center, 443 Via Ortega, Stanford, California 94305, United States; Department of Radiology, Stanford University School of Medicine, James H. Clark Center, 318 Campus Drive, E-153, Stanford, California 94305, United States.
Hamed AramiDepartment of Radiology, Stanford University School of Medicine, James H. Clark Center, 318 Campus Drive, E-153, Stanford, California 94305, United States; Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, James H. Clark Center, 318 Campus Drive, E-153, Stanford, California 94305, United States. Electronic address: arami1@stanford.edu.
Stanford University · US

Funding

STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Cancer-Translational Nanotechnology Training Program (Cancer-TNT)T32CA196585 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W, RAO, JIANGHONG · 2015 to 2019
$1.8M
Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain TumorsK99CA234208 · NCI · STANFORD UNIVERSITY · PI ARAMI, HAMED · 2020 to 2022
$477k
NCI NIH HHS K99 CA234208NCI NIH HHS T32 CA009695NCI NIH HHS T32 CA196585
6 · The paper itself

Abstract

Calcium phosphate is the inorganic mineral of hard tissues such as bone and teeth. Due to their similarities to the natural bone, calcium phosphates are highly biocompatible and biodegradable materials that have found numerous applications in dental and orthopedic implants and bone tissue engineering. In the form of nanoparticles, calcium phosphate nanoparticles (CaP's) can also be used as effective delivery vehicles to transfer therapeutic agents such as nucleic acids, drugs, proteins and enzymes into tumor cells. In addition, facile preparation and functionalization of CaP's, together with their inherent properties such as pH-dependent solubility provide advantages in delivery and release of these bioactive agents using CaP's as nanocarriers. In this review, the challenges and achievements in the intracellular delivery of these agents to tumor cells are discussed. Also, the most important issues in the design and potential applications of CaP-based biominerals are addressed with more focus on their biodegradability in tumor microenvironment.

Indexed as

Antineoplastic AgentsCalcium PhosphatesDrug CarriersHumansNanoparticlesNeoplasmsTissue EngineeringTumor MicroenvironmentAntineoplastic Agentscalcium phosphateCalcium PhosphatesDrug CarriersCalcium phosphateCancerDegradableDrug deliveryGene deliveryHydroxyapatiteIntracellular deliveryNanoparticles

Identifiers

PMID32330734
PMCPMC7261203
OpenAlexW3016200451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.