Evidence map›Paper›PMID 32330692›Full record

ArticleAtherosclerosis2020

Predictors of coronary artery calcium among 20-30-year-olds: The Coronary Artery Calcium Consortium.

Albert D Osei, S M Iftekhar Uddin, Omar Dzaye, Miguel Cainzos Achirica, Zeina A Dardari, Olufunmilayo H Obisesan, Sina Kianoush, Mohammadhassan Mirbolouk, Olusola A Orimoloye, Leslee Shaw and 8 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  14. The use of coronary artery calcium scoring in young adults.Journal of cardiovascular computed tomography
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

Albert D OseiJohns Hopkins University, Baltimore, MD, USA.
S M Iftekhar UddinJohns Hopkins University, Baltimore, MD, USA.
Omar DzayeJohns Hopkins University, Baltimore, MD, USA.
Miguel Cainzos AchiricaJohns Hopkins University, Baltimore, MD, USA.
Zeina A DardariJohns Hopkins University, Baltimore, MD, USA.
Olufunmilayo H ObisesanJohns Hopkins University, Baltimore, MD, USA.
Sina KianoushYale University, New Haven, CT, USA.
Mohammadhassan MirboloukYale University, New Haven, CT, USA.
Olusola A OrimoloyeVanderbilt University Medical Center, Nashville, TN, USA.
Leslee ShawWeill Cornell Medicine, New York, USA.
John A RumbergerPrinceton Longevity Center, Princeton, NJ, USA.
Daniel BermanCedars-Sinar Medical Center, California, USA.
Alan RozanskiDivision of Cardiology, Mount Sinai St, Luke's Hospital, USA.
Michael D MiedemaMinneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minnesota, USA.
Matthew J BudoffLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, LA, California, USA.
Ramachandran S VasanBoston University School of Medicine, Boston, MA, USA.
Khurram NasirHouston Methodist Hospital, Houston, TX, USA.
Michael J BlahaJohns Hopkins University, Baltimore, MD, USA. Electronic address: mblaha1@jhmi.edu.
Johns Hopkins University · USYale University · USCedars-Sinai Medical Center · USCornell University · USHarbor–UCLA Medical Center · USMethodist Hospital · USMinneapolis Heart Institute Foundation · USPrinceton University · USSt. Luke's Hospital · USVanderbilt University Medical Center · US

Funding

NHLBI NIH HHS L30 HL110027
6 · The paper itself

Abstract

BACKGROUND AND

aimsWe sought to understand the risk factor correlates of very early coronary artery calcium (CAC), and the potential investigational value of CAC phenotyping in adults aged 20-30 years.

methodsWe studied all participants aged 20-30 years at baseline (N = 373) in the Coronary Artery Calcium Consortium, a large multi-center cohort study of patients aged 18 years or older without known atherosclerotic cardiovascular disease (ASCVD) at baseline, referred for CAC scoring for clinical risk stratification. We described the prevalence of CAC in men and women, the frequency of risk factors by the presence of CAC (CAC = 0 vs CAC >0), and assessed the association between traditional non-demographic CVD risk factors (hypertension, hyperlipidemia, smoking, family history of CHD, and diabetes) and prevalent CAC, using age- and sex-adjusted logistic regression models.

resultsThe mean age of the study participants was 27.5 ± 2.4 years; 324 (86.9%) had CAC = 0, and 49 (13.1%) had CAC >0. Among the 49 participants with CAC, 38 (77.6%) were men, and median CAC score was low at 4.6. In age- and sex-adjusted models, there was a graded increase in the odds of CAC >0 with increasing traditional cardiovascular disease (CVD) risk factor burden (p = 0.001 for linear trend). Participants with ≥3 traditional risk factors had a statistically significant higher odds of having prevalent CAC (OR 5.57, 95% CI; 1.82-17.03) compared to participants with no risk factors.

conclusionsOur study demonstrates the non-negligible prevalence of CAC among very high-risk young US adults, reinforcing the critical importance of traditional risk factors in the earliest development of detectable subclinical ASCVD.

Indexed as

Coronary Artery DiseaseVascular CalcificationAdultCalciumCohort StudiesCoronary AngiographyCoronary VesselsFemaleHumansMaleRisk AssessmentRisk FactorsYoung AdultCalciumCardiovascular risk factorsCoronary artery calciumPredictorsPreventionYoung adults

Identifiers

PMID32330692
PMCPMC7260100
OpenAlexW3015546007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.