Evidence map›Paper›PMID 32330590›Full record

ArticleAlcohol (Fayetteville, N.Y.)2020

Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice.

Sema G Quadir, Christian D Rohl, Aya Zeabi, Catherine F Moore, Pietro Cottone, Valentina Sabino

Open access · greenAbstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sema G QuadirLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States.
Christian D RohlLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States.
Aya ZeabiLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States.
Catherine F MooreLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States.
Pietro CottoneLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States.
Valentina SabinoLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E. Concord St., Boston, MA, United States. Electronic address: vsabino@bu.edu.
Boston University · US

Funding

Involvement of neuropeptide systems in excessive alcohol drinkingR01AA025038 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABINO, VALENTINA · 2017 to 2021
$1.8M
Prefrontal cortex in excessive alcohol drinking: role of sigma receptorsR01AA024439 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABINO, VALENTINA · 2016 to 2020
$1.8M
Determining the role of PACAP neuronal populations in alcohol drinking using PACAP-Cre miceR21AA026051 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COTTONE, PIETRO · 2018 to 2019
$433k
NIAAA NIH HHS R01 AA024439NIAAA NIH HHS R01 AA025038NIAAA NIH HHS R21 AA026051
6 · The paper itself

Abstract

Alcohol is the most ubiquitously consumed and misused mind-altering substance in the world. Various animal models exist to aid in our neurobiological understanding of alcohol addiction. One variable too often taken for granted and not consistently controlled is the "standard" chow diet rodents are maintained on. In this set of experiments, we sought to determine the effect of different commonly used diets on ethanol intake, ethanol preference, and mechanical pain sensitivity in a widely used mouse model of heavy alcohol drinking, the intermittent access to 20% alcohol model. We found that male mice kept on LabDiet 5001 (Diet 2 [LD5001]) and on Teklad Diet 7012 (Diet 3 [H7012]) consistently drank more ethanol than mice kept on Teklad Diet 2918 (Diet 1 [H2918]) as well as compared to mice on LabDiet 5V75 (Diet 4 [LD5V75]). In addition, water intake was consistently lower in mice kept on LabDiet 5001 (Diet 2 [LD5001]), and occasionally in mice kept on Teklad Diet 7012 (Diet 3 [H7012]), compared to the Teklad Diet 2918 (Diet 1 [H2918]) group. We found that male mice showed a strong mechanical allodynia following 8 weeks of intermittent ethanol drinking at 72 h of withdrawal, compared to water Control mice, regardless of the diet and hence of the different amount of ethanol consumed. Our data provide evidence that the type of rodent diet subjects are exposed to is an important variable to report and control, in all ethanol drinking studies.

Indexed as

Alcohol DrinkingDietHyperalgesiaAnimalsEthanolMaleMiceMice, Inbred C57BLEthanoladdictionalcoholalcoholismanimal modeldependencedrinkingfoodhyperalgesiapain

Identifiers

PMID32330590
PMCPMC7812484
OpenAlexW3017619676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.