Evidence map›Paper›PMID 32330403›Full record

ArticleJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2020

Manufacturing of Dexamethasone-Poly(d,l-Lactide-co-Glycolide) Implants Using Hot-Melt Extrusion: Within- and Between-Batch Product Performance Comparisons.

Ryan A Kelley, Alireza Ghaffari, Yan Wang, Stephanie Choi, Jonathan R Taylor, Rachel R Hartman, Uday B Kompella

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Exploring the pivotal role of hot melt extrusion technology in developing PLGA based novel drug delivery platforms for better therapeutic outcomes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ryan A KelleySkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Alireza GhaffariSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Yan WangFood and Drug Administration, White Oak Campus, Silver Spring, Maryland.
Stephanie ChoiFood and Drug Administration, White Oak Campus, Silver Spring, Maryland.
Jonathan R TaylorSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Rachel R HartmanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Uday B KompellaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
University of Colorado Anschutz Medical Campus · USUnited States Food and Drug Administration · US

Funding

In Vitro-In Vivo Correlation of Ocular ImplantsU01FD004929 · FDA · UNIVERSITY OF COLORADO DENVER · PI KOMPELLA, UDAY B · 2013 to 2013
$565k
Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular BioavaiU01FD004719 · FDA · UNIVERSITY OF COLORADO DENVER · PI KOMPELLA, UDAY B · 2012 to 2012
$444k
Nonivasive Monitoring of Suprachoroidal DeliveryR21EY029887 · NEI · UNIVERSITY OF COLORADO DENVER · PI KOMPELLA, UDAY B · 2019 to 2020
$428k
FDA HHS U01 FD004719FDA HHS U01 FD004929NEI NIH HHS R21 EY029887
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Absorbable ImplantsAnti-Inflammatory AgentsBiocompatible MaterialsDelayed-Action PreparationsDexamethasoneDrug CompoundingDrug ImplantsDrug LiberationEye DiseasesHot Melt Extrusion TechnologyHumansInflammationInfusion Pumps, ImplantableIntravitreal InjectionsPolylactic Acid-Polyglycolic Acid CopolymerReproducibility of ResultsAnti-Inflammatory AgentsBiocompatible MaterialsDelayed-Action PreparationsDexamethasoneDrug ImplantsPolylactic Acid-Polyglycolic Acid Copolymerbiodegradable implantdexamethasonehot-melt extrusionintravitreal implantocular drug delivery

Identifiers

PMID32330403
PMCPMC7301315
OpenAlexW3018269951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.