ArticleBritish journal of haematology2020
COVID19 coagulopathy in Caucasian patients.
Article in British journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04470583 (Evaluation of Clinical Parameters Following COVID-19 Infection in Pregnancy), which is not on this map. Cited by 200 papers, 11 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Clinical Parameters Following COVID-19 Infection in Pregnancy (COpregVID)
Who cites it
200 citing papers in PubMed, 11 syntheses or guidelines pooled it, 422 citations in OpenAlex.
- Recommendations for treatment of critically ill patients with COVID-19 : Version 3 S1 guideline.Der Anaesthesist · 2021Guideline
- Thrombotic risk in children with COVID-19 infection: A systematic review of the literature.Thrombosis research · 2021Pooled it
- Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Ischemic gastrointestinal complications of COVID-19: a systematic review on imaging presentation.Clinical imaging · 2021Pooled it
- Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis.Thrombosis research · 2021Pooled it
- COVID-19 and coagulation dysfunction in adults: A systematic review and meta-analysis.Journal of medical virology · 2021Pooled it
- Pathological findings in organs and tissues of patients with COVID-19: A systematic review.PloS one · 2021Pooled it
- Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2021Pooled it
- Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic.Mayo Clinic proceedings · 2020Pooled it
- [German recommendations for treatment of critically ill patients with COVID-19-version 3 : S1-guideline].Der Anaesthesist · 2020Guideline
- Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Folic Acid and Endothelial Dysfunction in COVID-19.Life (Basel, Switzerland) · 2026Review
- Admission Serum Inflammatory and Injury Biomarkers Are Associated with In-Hospital Mortality in Neurological Inpatients with Confirmed SARS-CoV-2 Infection: The Brain-COVID Cohort Study.Current issues in molecular biology · 2026Article
- Cardio-Pulmonary Features of Long COVID: From Molecular and Histopathological Characteristics to Clinical Implications.International journal of molecular sciences · 2025Review
- Chest computed tomography and plain radiographs demonstrate vascular distribution and characteristics in COVID-19 lung disease - a pulmonary vasculopathy.The Ulster medical journal · 2025Article
- The Role of Sterile Inflammation in Thrombosis: Consequences for Cardiovascular Disease and COVID-19.Mediators of inflammation · 2025Review
- Immunity and Coagulation in COVID-19.International journal of molecular sciences · 2024Review
- The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients.Journal of clinical medicine · 2024Article
- Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not: A systematic review and meta-analysis.World journal of methodology · 2024Article
- Symptom burden, coagulopathy and heart disease after acute SARS-CoV-2 infection in primary practice.Scientific reports · 2024Observational
140 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
Although the pathophysiology underlying severe COVID19 remains poorly understood, accumulating data suggest that a lung-centric coagulopathy may play an important role. Elevated D-dimer levels which correlated inversely with overall survival were recently reported in Chinese cohort studies. Critically however, ethnicity has major effects on thrombotic risk, with a 3-4-fold lower risk in Chinese compared to Caucasians and a significantly higher risk in African-Americans. In this study, we investigated COVID19 coagulopathy in Caucasian patients. Our findings confirm that severe COVID19 infection is associated with a significant coagulopathy that correlates with disease severity. Importantly however, Caucasian COVID19 patients on low molecular weight heparin thromboprophylaxis rarely develop overt disseminated intravascular coagulation (DIC). In rare COVID19 cases where DIC does develop, it tends to be restricted to late-stage disease. Collectively, these data suggest that the diffuse bilateral pulmonary inflammation observed in COVID19 is associated with a novel pulmonary-specific vasculopathy termed pulmonary intravascular coagulopathy (PIC) as distinct to DIC. Given that thrombotic risk is significantly impacted by race, coupled with the accumulating evidence that coagulopathy is important in COVID19 pathogenesis, our findings raise the intriguing possibility that pulmonary vasculopathy may contribute to the unexplained differences that are beginning to emerge highlighting racial susceptibility to COVID19 mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.