ArticlePLoS pathogens2020
Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- Dietary vitamin A restricts intestinal tuft cell differentiation.Cell reports · 2026Article
- The gut microbiota directs vitamin A flux to regulate intestinal T cell development.Cell host & microbe · 2026Article
- The gut microbiota directs vitamin A flux to regulate intestinal T cell development.bioRxiv : the preprint server for biology · 2025Article
- Article
- Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose.Science translational medicine · 2024Article
- Review
- Epithelial regulation of microbiota-immune cell dynamics.Mucosal immunology · 2024Review
- Synergistic Effect of Retinoic Acid and Lactoferrin in the Maintenance of Gut Homeostasis.Biomolecules · 2024Review
- Review
- Gut commensals expand vitamin A metabolic capacity of the mammalian host.Cell host & microbe · 2022Article
- Epithelial Pyroptosis in Host Defense.Journal of molecular biology · 2022Review
- Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022Review
- Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection.Cell host & microbe · 2021Article
- Innate immune sensing by epithelial barriers.Current opinion in immunology · 2021Review
- Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease.Nutrients · 2021Review
- Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.Mucosal immunology · 2021Article
- Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review.Journal of inflammation research · 2021Review
- Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function.Frontiers in immunology · 2021Review
- Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota.Frontiers in nutrition · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions, coordinating a cascade of immune responses to protect against pathogens. Here we show that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in the infection and subsequently activates immune cells to promote pathogen clearance. Mice blocked for retinoic acid receptor (RAR) signaling selectively in IECs (stopΔIEC) showed higher Salmonella burden in colonic tissues early in the infection that associated with higher luminal and systemic loads of the pathogen at later stages. Higher pathogen burden in stopΔIEC mice correlated with attenuated mucosal interferon gamma (IFNγ) production by underlying immune cells. We found that, at homeostasis, the intestinal epithelium of stopΔIEC mice produced significantly lower amounts of interleukin 18 (IL-18), a potent inducer of IFNγ. Regulation of IL-18 by vitamin A was also observed in a dietary model of vitamin A supplementation. IL-18 reconstitution in stopΔIEC mice restored resistance to Salmonella by promoting epithelial cell shedding to eliminate infected cells and limit pathogen invasion early in infection. Further, IL-18 augmented IFNγ production by underlying immune cells to restrict pathogen burden and systemic spread. Our work uncovers a critical role for vitamin A in coordinating a biphasic immune response to Salmonella infection by regulating IL-18 production by IECs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.