Evidence map›Paper›PMID 32330121›Full record

ArticleAging2020

Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21

Yun Yeong Lee, Yeon Seung Choi, Do Wan Kim, Jae Youn Cheong, Kye Yong Song, Min Sook Ryu, In Kyoung Lim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Mitochondrial regulation of cellular senescence heterogeneity.Frontiers in cell and developmental biology · 2026
    Review
  2. Review
  3. A novel mutation inAging · 2021
    Article
  4. Article
  5. P53 in the impaired lungs.DNA repair · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yun Yeong LeeDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea.
Yeon Seung ChoiDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea.
Do Wan KimOmics Center, Ajou University School of Medicine, Suwon 16499, Korea.
Jae Youn CheongOmics Center, Ajou University School of Medicine, Suwon 16499, Korea.
Kye Yong SongDepartment of Pathology, Chung-Ang University College of Medicine, Seoul 156-756, Korea.
Min Sook RyuDepartment of Biomedical Sciences, The Graduate School, Ajou University, Suwon 16499, Korea.
In Kyoung LimDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea.
Ajou University · KRChung-Ang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction is linked to age-related senescence phenotypes. We report here the pathway increasing nucleoid remodeling and biogenesis in mitochondria during the senescence of foreskin human diploid fibroblasts (fs-HDF) and WI-38 cells. Replicative senescence in fs-HDF cells increased mitochondrial nucleoid remodeling as indicated by 5-bromo-2'-deoxyuridine (BrdU) incorporation and mitochondrial transcription factor A (TFAM) expression in enlarged and fused mitochondria. Mitochondrial nucleoid remodeling was accompanied by mitochondrial biogenesis in old cells, and the expression levels of OXPHOS complex-I, -IV and -V subunits, PGC-1α and NRF1 were greatly increased compared to young cells. Activated protein kinase C zeta (PKCζ) increased mitochondrial activity and expressed phenotypes of delayed senescence in fs-HDF cells, but not in WI-38 cells. The findings were reproduced in the doxorubicin-induced senescence of young fs-HDF and WI-38 cells

Indexed as

Cellular SenescenceOrganelle BiogenesisAMP-Activated Protein Kinase KinasesCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsDNA, MitochondrialDoxorubicinFibroblastsGene SilencingHumansMitochondriaMitochondrial ProteinsNuclear Respiratory Factor 1Oxidative PhosphorylationPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAMP-Activated Protein Kinase KinasesCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsDNA, MitochondrialDoxorubicinMitochondrial ProteinsNRF1 protein, humanNuclear Respiratory Factor 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanProtein Kinase CProtein Kinase C zetaProtein Serine-Threonine KinasesSTK11 protein, humanTFAM protein, humanTopoisomerase II InhibitorsTranscription FactorsTumor Suppressor Protein p53mitochondrianucleoid remodelingp16INK4a silencep53-p21-PKCζ activationsenescence

Identifiers

PMID32330121
PMCPMC7202532
OpenAlexW3019728569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.