Evidence map›Paper›PMID 32330104›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020

Consistent Physical Activity and Future Neurocognitive Problems in Adult Survivors of Childhood Cancers: A Report From the Childhood Cancer Survivor Study.

Emily Barlow-Krelina, Yan Chen, Yutaka Yasui, Christine Till, Todd M Gibson, Kirsten K Ness, Wendy M Leisenring, Rebecca M Howell, Paul C Nathan, Kevin C Oeffinger and 4 more

Abstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. The association of perceived health status and presence of chronic conditions with physical activity in childhood cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Article
  5. Aging and cancer.Molecular cancer · 2024
    Review
  6. Article
  7. Article
  8. Risk factors and screening for neurocognitive impacts of therapy.Hematology. American Society of Hematology. Education Program · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Aging in Adult Survivors of Childhood Cancer: Implications for Future Care.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emily Barlow-KrelinaYork University, Toronto, Ontario, Canada.
Yan ChenUniversity of Alberta, Edmonton, Alberta, Canada.
Yutaka YasuiUniversity of Alberta, Edmonton, Alberta, Canada.
Christine TillYork University, Toronto, Ontario, Canada.
Todd M GibsonSt Jude Children's Research Hospital, Memphis, TN.
Kirsten K NessSt Jude Children's Research Hospital, Memphis, TN.
Wendy M LeisenringFred Hutchinson Cancer Research Center, Seattle, WA.
Rebecca M HowellMD Anderson Cancer Center, Houston, TX.
Paul C NathanHospital for Sick Children, Toronto, Ontario, Canada.
Kevin C OeffingerDuke Cancer Institute, Durham, NC.
Leslie L RobisonSt Jude Children's Research Hospital, Memphis, TN.
Gregory T ArmstrongSt Jude Children's Research Hospital, Memphis, TN.
Kevin R KrullSt Jude Children's Research Hospital, Memphis, TN.
Kim EdelsteinPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.

Funding

Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
CIHR 379609NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

purposeTo investigate longitudinal associations between physical activity (PA) and neurocognitive problems in adult survivors of childhood cancer.

methodsA total of 12,123 5-year survivors diagnosed between 1970 and 1999 (median [range] age at diagnosis, 7 [0-21] years, time since diagnosis at baseline, 16 [6-30] years) and 720 siblings self-reported PA and neurocognitive problems. PA was collected at baseline, and PA and neurocognitive data were obtained 7 (1-12) years and 12 (9-14) years later. PA consistency was defined as any combination of ≥ 75 minutes of vigorous or 150 minutes of moderate activity per week on all surveys. Multiple linear regressions, conducted separately for CNS and non-CNS survivors, identified associations between PA consistency and neurocognitive outcomes (expected mean, 50; standard deviation [SD], 10). Mediating effects of body mass index (BMI) and chronic health conditions (CHCs) were evaluated.

resultsSurvivors were less likely than siblings to report consistent PA (28.1%

conclusionAdult survivors of childhood cancer who report more consistent PA have fewer neurocognitive problems and larger improvements in these concerns many years after treatment.

Indexed as

ExerciseAdultCancer SurvivorsCognition DisordersFemaleHumansMaleRetrospective StudiesSelf Report

Identifiers

PMID32330104
PMCPMC7302957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.