Evidence map›Paper›PMID 32329986›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Transcranial magnetic stimulation over the right temporoparietal junction influences the sense of agency in healthy humans.

Giuseppe A Zito, Laura B Anderegg, Kallia Apazoglou, René M Müri, Roland Wiest, Martin Grosse Holtforth, Selma Aybek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Giuseppe A ZitoFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
Laura B AndereggFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
Kallia ApazoglouFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
René M MüriFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
Roland WiestFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
Martin Grosse HoltforthFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
Selma AybekFrom the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Anderegg, Müri, Holtforth, Aybek); the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (Zito, Wiest); Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland (Apazoglou); the Perception and Eye Movement Laboratory, Department of Neurology and Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland (Müri); and the Institute of Psychology, University of Bern, Bern, Switzerland (Holtforth).
University Hospital of Bern · CHUniversity of Bern · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The sense of agency is an important aspect of motor control. Impaired sense of agency has been linked to several medical conditions, including schizophrenia and functional neurological disorders. A complex brain network subserves the sense of agency, and the right temporoparietal junction is one of its main nodes. In this paper, we tested whether transcranial magnetic stimulation over the right temporoparietal junction elicited behavioural changes in the sense of agency. Methods: In experiment 1, 15 healthy participants performed a behavioural task during functional MRI, with the goal of localizing the area relevant for the sense of agency in the right temporoparietal junction. In the task, the movement of a cursor (controlled by the participants) was artificially manipulated, and the sense of agency was either diminished (turbulence) or enhanced (magic). In experiment 2, we applied transcranial magnetic stimulation in 20 healthy participants in a sham-controlled, crossover trial with excitatory, inhibitory or sham (vertex) stimulation. We measured the summary agency score, an indicator of the sense of agency (lower values correspond to diminished sense of agency). Results: Experiment 1 revealed a peak of activation during agency manipulation in the right temporoparietal junction (Montreal Neurological Institute coordinates x, y, z: 68, -26, 34). Experiment 2 showed that inhibition of the right temporoparietal junction significantly reduced the summary agency score in both turbulence (from -14.4 ± 11.4% to -22.5 ± 8.9%), and magic (from -0.7 ± 5.8% to -4.4 ± 4.4%). Limitations: We found no excitatory effects, possibly because of a ceiling effect (because healthy participants have a normal sense of agency) or noneffectiveness of the excitatory protocol. Conclusion: Our experiments showed that the network subserving the sense of agency was amenable to neuromodulation in healthy participants. This sets the ground for further research in patients with impaired sense of agency. Clinical trial identification: DRKS00012992 (German clinical trials registry).

Indexed as

Internal-External ControlTranscranial Magnetic StimulationAdultFemaleFunctional NeuroimagingHealthy VolunteersHumansMagnetic Resonance ImagingMaleNeural InhibitionParietal LobeTemporal LobeYoung Adult

Identifiers

PMID32329986
PMCPMC7828927
OpenAlexW3020468519

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.