ArticleHuman brain mapping2020
Language lateralization from task-based and resting state functional MRI in patients with epilepsy.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.Epilepsia · 2026Article
- Spatially constrained ICA from a language task enables sensorimotor network extraction in patients with space-occupying brain lesions.Brain imaging and behavior · 2026Article
- Modeling Complex Effects and Individual Variability in Multi-Paradigm fMRI with Nonlinear Mixed Models.bioRxiv : the preprint server for biology · 2026Article
- A Rapid fMRI Paradigm for Localisation of the Language Network.The European journal of neuroscience · 2026Article
- Hemispheric Network Dynamics During Auditory Language Comprehension and Its Clinical Implications Regarding Resting-State Functional Magnetic Resonance Imaging.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Noninvasive imaging techniques to map language areas using BOLD signal fluctuations in pediatric epilepsy: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Theoretical, Technical, and Analytical Foundations of Task-Based and Resting-State Functional Magnetic Resonance Imaging (fMRI)-A Narrative Review.Biomedicines · 2026Review
- Does white matter structure relate to hemispheric language lateralization? A systematic review.Brain communications · 2026Review
- Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.medRxiv : the preprint server for health sciences · 2025Article
- Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory.Human brain mapping · 2025Article
- Robust-tedana: An automated denoising pipeline for multi-echo fMRI data.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization.Journal of imaging informatics in medicine · 2025Article
- Exploring the Relationship Between White Matter Tracts and Resting-State Functional Language Lateralization Index.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Modeling functional connectivity changes during an auditory language task using line graph neural networks.Frontiers in computational neuroscience · 2024Article
- Evaluating the concordance of functional MRI-based language lateralization and Wada testing in epilepsy patients: A single-center analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Resting-state functional alterations in patients with brain arteriovenous malformations involving language areas.Human brain mapping · 2023Article
- Diffusion magnetic resonance imaging connectome features are predictive of functional lateralization of semantic processing in the anterior temporal lobes.Human brain mapping · 2023Article
- Occupation-modulated language networks and its lateralization: A resting-state fMRI study of seafarers.Frontiers in human neuroscience · 2023Article
- Right-hemispheric language reorganization in patients with brain arteriovenous malformations: A functional magnetic resonance imaging study.Human brain mapping · 2021Article
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7 authors.
Funding
Abstract
We compared resting state (RS) functional connectivity and task-based fMRI to lateralize language dominance in 30 epilepsy patients (mean age = 33; SD = 11; 12 female), a measure used for presurgical planning. Language laterality index (LI) was calculated from task fMRI in frontal, temporal, and frontal + temporal regional masks using LI bootstrap method from SPM12. RS language LI was assessed using two novel methods of calculating RS language LI from bilateral Broca's area seed based connectivity maps across regional masks and multiple thresholds (p < .05, p < .01, p < .001, top 10% connections). We compared LI from task and RS fMRI continuous values and dominance classifications. We found significant positive correlations between task LI and RS LI when functional connectivity thresholds were set to the top 10% of connections. Concordance of dominance classifications ranged from 20% to 30% for the intrahemispheric resting state LI method and 50% to 63% for the resting state LI intra- minus interhemispheric difference method. Approximately 40% of patients left dominant on task showed RS bilateral dominance. There was no difference in LI concordance between patients with right-sided and left-sided resections. Early seizure onset (<6 years old) was not associated with atypical language dominance during task-based or RS fMRI. While a relationship between task LI and RS LI exists in patients with epilepsy, language dominance is less lateralized on RS than task fMRI. Concordance of language dominance classifications between task and resting state fMRI depends on brain regions surveyed and RS LI calculation method.
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