ArticlePhysical therapy2020
Efficacy of Supporting Play Exploration and Early Development Intervention in the First Months of Life for Infants Born Very Preterm: 3-Arm Randomized Clinical Trial Protocol.
Article in Physical therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04889846 (Investigation of the Effectiveness of Family Collaborative Early Intervention Approach Based on Sensory Strategies, Activity Based Motor Training and Environmental Enrichment in Premature Infants), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effectiveness of Family Collaborative Early Intervention Approach Based on Sensory Strategies, Activity Based Motor Training and Environmental Enrichment in Premature Infants: SAFE National Early Intervention Approach
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Motor interventions initiated prior hospital discharge to prevent neurodevelopmental impairment in preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Short-term effects of SAFE early intervention approach in infants born preterm: A randomized controlled single-blinded study.Brain and behavior · 2023Trial
- Longitudinal Changes in the Sensorimotor Pathways of Very Preterm Infants During the First Year of Life With and Without Intervention: A Pilot Study.Developmental neurorehabilitation · 2021Trial
- Effectiveness of Early Physiotherapy Interventions with Guided Parental Involvement on Motor Development in Preterm Infants: A Systematic Review.Pediatric reports · 2026Review
- Experience-based co-design to refine a remote parent-mediated intervention program for preterm infants after NICU discharge: a qualitative study.BMC pediatrics · 2026Article
- Gross Motor Function Measure-66 Item Sets for use with infants and toddlers at high risk for cerebral palsy: Construct validity and responsiveness.Developmental medicine and child neurology · 2025Article
- Article
- The Homeostasis-Enrichment-Plasticity (HEPJournal of clinical medicine · 2024Article
- Relationship Between Prone Skills and Motor-Based Problem-Solving Abilities in Full-Term and Preterm Infants During the First 6 Months of Life.Developmental psychobiology · 2024Article
- The Importance of Follow-Up Visits for Children at Risk of Developmental Delay-A Review.Diagnostics (Basel, Switzerland) · 2024Review
- A Feasibility Study of a Physical and Occupational Therapy-Led and Parent-Administered Program to Improve Parent Mental Health and Infant Development.Physical & occupational therapy in pediatrics · 2024Article
- Cross-cultural adaptation of the Neonatal Medical Index (NMI) to Brazil.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Article
- Spanish Translation and Cultural Adaptations of Physical Therapy Parent Educational Materials for Use in Neonatal Intensive Care.Patient preference and adherence · 2024Article
- Parent and Therapist Perceptions of the Feasibility, Acceptability, and Benefits of a Weekly Therapist-Led Massage Program for Extremely Preterm Infants in Neonatal Intensive Care.Children (Basel, Switzerland) · 2023Article
- [Research hotspots in post-discharge follow-up management of preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Factors Influencing Receipt and Type of Therapy Services in the NICU.Behavioral sciences (Basel, Switzerland) · 2023Article
- Parent Experiences in the NICU and Transition to Home.International journal of environmental research and public health · 2023Article
- Motor Development Comparison between Preterm and Full-Term Infants Using Alberta Infant Motor Scale.International journal of environmental research and public health · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe aim of this project is to study the effect of a physical therapist intervention provided in the first months of life on developmental outcomes of infants born very preterm. Secondary aims are to investigate the impact of intervention timing on the efficacy and impact of the intervention on infants with and without cerebral palsy.
methodsThis study is a multisite longitudinal controlled trial comparing developmental outcomes from infants in the Supporting Play, Exploration, and Early Development Intervention (SPEEDI)_Late or SPEEDI_Early group to a usual care group. SETTINGS ARE URBAN: Urban and rural areas surrounding 2 academic medical centers. There will be 90 preterm infants enrolled in this study born at <29 weeks of gestation. SPEEDI is a developmental intervention provided by collaboration between a physical therapist and parent to support a child's motor and cognitive development. The primary outcome measure is the Bayley Scale of Infant and Toddler Development Cognitive and Gross Motor Scaled Scores. Secondary measures include behavioral coding of early problem solving skills, the Gross Motor Function Measure, and Test of Infant Motor Performance. IMPACT: More than 270,000 infants are born very preterm in the United States each year, 50% of whom will have neurological dysfunction that limits their ability to keep pace with peers who are typically developing. This study is a step toward understanding the impact that intensive developmental intervention could have in this population in the first months of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.