Evidence map›Paper›PMID 32329609›Full record

ArticleBioconjugate chemistry2020

Covalently Immobilizing Interferon-γ Drives Filopodia Production through Specific Receptor-Ligand Interactions Independently of Canonical Downstream Signaling.

Shaun M Christie, Trevor R Ham, Grant T Gilmore, Paul D Toth, Nic D Leipzig, Adam W Smith

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shaun M ChristieDepartment of Chemistry, The University of Akron, 190 Buchtel Common, Akron, Ohio 44325, United States.
Trevor R HamDepartment of Biomedical Engineering, The University of Akron, Auburn Science and Engineering Center #275, West Tower, Akron, Ohio 44325, United States.
Grant T GilmoreDepartment of Chemistry, The University of Akron, 190 Buchtel Common, Akron, Ohio 44325, United States.
Paul D TothDepartment of Chemistry, The University of Akron, 190 Buchtel Common, Akron, Ohio 44325, United States.
Nic D LeipzigDepartment of Biomedical Engineering, The University of Akron, Auburn Science and Engineering Center #275, West Tower, Akron, Ohio 44325, United States.ORCID 0000-0002-6356-7691
Adam W SmithDepartment of Chemistry, The University of Akron, 190 Buchtel Common, Akron, Ohio 44325, United States.ORCID 0000-0001-5216-9017
University of Akron · US

Funding

Central Nervous System Tissue Organogenesis via Precise Growth Factor TetheringR21NS096571 · NINDS · UNIVERSITY OF AKRON · PI LEIPZIG, NIC D · 2016 to 2017
$418k
NINDS NIH HHS R21 NS096571
6 · The paper itself

Abstract

Immobilizing a signaling protein to guide cell behavior has been employed in a wide variety of studies. This approach draws inspiration from biology, where specific, affinity-based interactions between membrane receptors and immobilized proteins in the extracellular matrix guide many developmental and homeostatic processes. Synthetic immobilization approaches, however, do not necessarily recapitulate the

Indexed as

Signal TransductionAnimalsChlorocebus aethiopsCOS CellsImmobilized ProteinsInterferon-gammaInterferon gamma ReceptorLigandsPseudopodiaReceptors, InterferonTransfectionImmobilized ProteinsInterferon-gammaInterferon gamma ReceptorLigandsReceptors, Interferon

Identifiers

PMID32329609
PMCPMC10243121
OpenAlexW3018011950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.