ArticleHuman brain mapping2020
Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Electrophysiological resting-state signatures link polygenic scores to general intelligence.Scientific reports · 2025Observational
- Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.Translational psychiatry · 2024Article
- Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture.Research square · 2023Article
- Structural architecture and brain network efficiency link polygenic scores to intelligence.Human brain mapping · 2023Article
- TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.Genes, brain, and behavior · 2023Article
- A cognitive neurogenetic approach to uncovering the structure of executive functions.Nature communications · 2022Article
- Shared genetic influences on resting-state functional networks of the brain.Human brain mapping · 2022Article
- Twin studies to GWAS: there and back again.Trends in cognitive sciences · 2021Review
- Intergenerational transmission of the patterns of functional and structural brain networks.iScience · 2021Article
- Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns.Human brain mapping · 2020Article
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15 authors.
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Abstract
Resting-state functional connectivity profiles have been increasingly shown to be important endophenotypes that are tightly linked to human cognitive functions and psychiatric diseases, yet the genetic architecture of this multidimensional trait is barely understood. Using a unique sample of 1,704 unrelated, young and healthy Chinese Han individuals, we revealed a significant heritability of functional connectivity patterns in the whole brain and several subnetworks. We further proposed a partitioned heritability analysis for multidimensional functional connectivity patterns, which revealed the common and unique enrichment patterns of the genetic contributions to brain connectivity patterns for several gene sets linked to brain functions, including the genes expressed preferentially in the central nervous system and those associated with intelligence, educational attainment, attention-deficit/hyperactivity disorder, and schizophrenia. These results for the first time reveal the genetic architecture of multidimensional brain connectivity patterns across different networks and advance our understanding of the complex relationship between gene sets, neural networks, and behaviors.
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