Evidence map›Paper›PMID 32329301›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2020

Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis.

Liyao Song, Xiaomei Luo, Qing Jiang, Zhi Chen, Lifang Zhou, Dan Wang, Ai Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Article
  7. Article
  8. Article
  9. Relationship between 25(OH)DFrontiers in pediatrics · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Effects of Vitamin D Supplementation on Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
    Review
  14. Article
  15. Article
  16. Review
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  18. Article
  19. Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Liyao SongDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0001-9876-0013
Xiaomei LuoDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0002-2744-6809
Qing JiangDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0001-9421-797X
Zhi ChenNursing Department, The Affiliated Hospital of Southwest Medical University, Luzhou.ORCID https://orcid.org/0000-0002-8005-2307
Lifang ZhouDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0002-0887-7451
Dan WangDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0003-2128-2599
Ai ChenDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0003-3120-4949
Affiliated Hospital of Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder.

methodsWe systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation.

resultsThere was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (

conclusionVitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.

Indexed as

Autism spectrum disorderChildrenMeta-analysis.Vitamin D

Identifiers

PMID32329301
PMCPMC7242097
OpenAlexW3018647344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.