ArticleChembiochem : a European journal of chemical biology2020
Synergistic Interactions Are Prevalent in Catalytic Amyloids.
Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Conserved catalytic motifs encode enzyme-like supramolecular peptide assemblies.Research square · 2026Article
- Structure-activity relationships in catalytic amyloids.Journal of inorganic biochemistry · 2026Article
- Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production.Angewandte Chemie (International ed. in English) · 2025Article
- Cascade autohydrolysis of Alzheimer's Aβ peptides.Chemical science · 2023Article
- Catalytic amyloids: Is misfolding folding?Current opinion in chemical biology · 2021Review
- From structure to application: Progress and opportunities in peptide materials development.Current opinion in chemical biology · 2021Review
- Catalytic Amyloids as Novel Synthetic Hydrolases.International journal of molecular sciences · 2021Review
- Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids.Chembiochem : a European journal of chemical biology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Interactions between multiple functional groups are key to catalysis. Previously, we reported synergistic interactions in catalytic amyloids formed by mixtures of heptameric peptides that lead to significant improvements in esterase activity. Herein, we describe the in-depth investigation of synergistic interactions within a family of amyloid fibrils, exploring the results of functional group interactions, the effects of chirality and the use of mixed enantiomers within fibrils. Remarkably, we find that synergistic interactions (either positive or negative) are found in the vast majority of binary mixtures of catalytic amyloid-forming peptides. The productive arrangements of functionalities rapidly identified by mixing different peptides will undoubtedly lead to the development of more active catalysts for a variety of different transformations.
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Registered trials
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