ArticleBiological trace element research2021
Nano-selenium Supplementation Increases Selenoprotein (Sel) Gene Expression Profiles and Milk Selenium Concentration in Lactating Dairy Cows.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Precision dietary strategies for enriching animal-derived foods with antioxidants and omega-3 fatty acids.Veterinary and animal science · 2026Review
- Effects of Selenium Supplementation on Growth Performance, Antioxidant and Metabolic Status in Fattening Lambs: A Systematic Review and Meta-Analysis.Biological trace element research · 2026Review
- Microbial Synthesis of Nano Trace Minerals: A Comprehensive Review on Synthesis, Characterization, Biological Effects and Applications in Farm Animals.Biological trace element research · 2026Review
- Role of selenium in cow fertility and reproduction-A review.Veterinary research communications · 2026Review
- Milk profiles of selenoamino acids, selenoenzymes, and selenoproteins of peripartal dairy cows fed with different selenium sources.Animal bioscience · 2025Article
- Emerging trends of biomedical nanotechnology in nutrition, health monitoring and disease diagnosis.3 Biotech · 2025Review
- Effects of nanoselenium supplementation on lactation performance, nutrient digestion and mammary gland development in dairy cows.Animal biotechnology · 2024Article
- The Role of Selenitetriglycerides in Enhancing Antioxidant Defense Mechanisms in Peripartum Holstein-Friesian Cows.Animals : an open access journal from MDPI · 2024Article
- Effects of nanoselenium on the performance, blood indices, and milk metabolites of dairy cows during the peak lactation period.Frontiers in veterinary science · 2024Article
- Response of rumen fermentation and microbiota to dietary supplementation of sodium selenite and bio-nanostructured selenium in lactating Barki sheep.BMC veterinary research · 2023Article
- Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine.Pharmaceutics · 2023Review
- Synthesis and in Silico Investigation of Organoselenium-Clubbed Schiff Bases as Potential MLife (Basel, Switzerland) · 2023Article
- Effects of PUFA-Rich Dietary Strategies on Ruminants' Mammary Gland Gene Network: A Nutrigenomics Review.Metabolites · 2022Review
- The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry.The veterinary quarterly · 2022Review
- Thyroidal and Extrathyroidal Requirements for Iodine and Selenium: A Combined Evolutionary and (Patho)Physiological Approach.Nutrients · 2022Review
- Toxicological effects of nanoselenium in animals.Journal of animal science and biotechnology · 2022Review
- Nanominerals: Fabrication Methods, Benefits and Hazards, and Their Applications in Ruminants with Special Reference to Selenium and Zinc Nanoparticles.Animals : an open access journal from MDPI · 2021Review
- Nano-selenium on reproduction and immunocompetence: an emerging progress and prospect in the productivity of poultry research.Tropical animal health and production · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Supplementation with selenium is common for dairy cows, but the importance of selenium source is not clear. This study aimed to compare nano-selenium (Nano-Se) and sodium selenite supplements for dairy cows on lactation performance, milk Se levels and selenoprotein (Sel) gene expression. Twelve multiparous Holstein cows were randomly divided into two groups: a control group fed a basal diet plus 0.30 mg Se/kg of DM as sodium selenite or Nano-Se for 30 days. Dry matter intake, milk yield and composition were not affected by dietary Se source (P > 0.05); however, the milk total Se levels and milk glutathione peroxidase (GSH-Px) activities were higher with Nano-Se supplementation than sodium selenite (P < 0.05). At the end of the experiment, Nano-Se supplementation significantly increased plasma Se levels and GSH-Px activity, compared with the sodium selenite supplement. The mRNA expression levels of glutathione peroxidase 1, 2 and 4; thioredoxin reductase 2 and 3; and selenoproteins W, T, K and F were markedly upregulated (P < 0.05) in the mammary gland of the Nano-Se group. Thus, the source of selenium plays an important role in the antioxidant status and in particular the Sel gene expression in the mammary glands of dairy cows, both being stimulated by nano sources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.