ArticleMycopathologia2020
Antifungal Activity of Magnesium Oxide Nanoparticles: Effect on the Growth and Key Virulence Factors of Candida albicans.
Article in Mycopathologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Assessing graphite schist as a supplementary cementitious material in concrete for antifungal activity, strength, hydration, microstructure, and radiation shielding.Scientific reports · 2026Article
- Salvia sclarea L. mediated green synthesis of gold nanoparticles (AuNPs) and evaluation of their antibacterial, anticandidal, and scolicidal properties.Scientific reports · 2025Article
- Green-Synthesized MgO Nanoparticles: Structural Insights and Antimicrobial Applications.International journal of molecular sciences · 2025Article
- Towards Safe and Effective Biomedical Nanocoatings: Plasma-Sputtered Magnesium-Based Nanoparticles with Cytoprotective, Antimicrobial and Antialgal Properties.Molecules (Basel, Switzerland) · 2025Article
- Synthesis and antifungal evaluation against Candida spp. of the (E)-3-(furan-2-yl)acrylic acid.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Silver and Antimicrobial Polymer Nanocomplexes to Enhance Biocidal Effects.International journal of molecular sciences · 2024Article
- Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans?Mycopathologia · 2023Article
- The mechanistic effects of human digestion on magnesium oxide nanoparticles: implications for probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium bifidum VPI 1124.Environmental science. Nano · 2022Article
- Biological and Physico-Chemical Properties of Composite Layers Based on Magnesium-Doped Hydroxyapatite in Chitosan Matrix.Micromachines · 2022Article
- Mung Bean (Plants (Basel, Switzerland) · 2022Article
- Biomaterials for the Prevention of Oral Candidiasis Development.Pharmaceutics · 2021Review
- Mechanistic Understanding ofFrontiers in microbiology · 2021Review
- Bursting the Virulence Traits of MDR Strain ofInternational journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this research was to study the effects of different concentrations of magnesium oxide nanoparticles (MgO NPs) on the growth and key virulence factors of Candida albicans (C. albicans). The minimum inhibitory concentration (MIC) of MgO NPs against C. albicans was determined by the micro-broth dilution method. A time-kill curve of MgO NPs and C. albicans was established to investigate the ageing effect of MgO NPs on C. albicans. Crystal violet staining, the MTT assay, and inverted fluorescence microscopy were employed to determine the effects of MgO NPs on C. albicans adhesion, two-phase morphological transformation, biofilm biomass, and metabolic activity. The time-kill curve showed that MgO NPs had fungicidal and antifungal activity against C. albicans in a time- and concentration-dependent manner. Semi-quantitative crystal violet staining and MTT assays showed that MgO NPs significantly inhibited C. albicans biofilm formation and metabolic activity, and the difference was statistically significant (p < 0.001). Inverted fluorescence microscopy showed that MgO NPs could inhibit the formation of C. albicans biofilm hyphae. Adhesion experiments showed that MgO NPs significantly inhibited the initial adhesion of C. albicans (p < 0.001). This study demonstrates that MgO NPs can effectively inhibit the growth, initial adhesion, two-phase morphological transformation, and biofilm formation of C. albicans and is an antifungal candidate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.