ArticleJournal of natural medicines2020
Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities.
Article in Journal of natural medicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Evaluating the Antiplasmodial Activity ofScientifica · 2025Article
- Ceramicines U-Z from Chisocheton ceramicus and structure-antimalarial activity relationship study.Journal of natural medicines · 2024Article
- Antimalarial ceramicines Q-T from Chisocheton ceramicus.Journal of natural medicines · 2023Article
- Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida.Journal of natural medicines · 2021Article
- Bisindole alkaloids from Voacanga grandifolia leaves.Journal of natural medicines · 2021Article
- Triterpenoids from Walsura trichostemon.Journal of natural medicines · 2021Article
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three new quassinoids, javanicinols A and B (1 and 2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4-6) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1-3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), which were previously isolated from the Picrasma javanica wood.
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