Evidence map›Paper›PMID 32328824›Full record

ArticleSurgical endoscopy2021

Comprehensive Analysis of Adverse Events Associated with Gastric Peroral Endoscopic Myotomy: An International Multicenter Study.

Y Ichkhanian, K Vosoughi, M Aghaie Meybodi, J Jacques, A Sethi, A A Patel, A A Aadam, J R Triggs, A Bapaye, S Dorwat and 15 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Effective factors of peroral endoscopic myotomy for treatment of achalasia.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022
    Article
  12. POEM, GPOEM, and ZPOEM.Digestive diseases and sciences · 2022
    Review
  13. Navigational tunnel technique for gastric peroral endoscopic pyloromyotomy: getting straight to the point (pylorus).VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2022
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Y Ichkhanian *Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
K Vosoughi *Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
M Aghaie MeybodiDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
J JacquesGastroenterology Department, Limoges University Hospital, 2 Avenue Martin Luther King, 87042, Rouen, France.
A SethiDivision of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
A A PatelDivision of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
A A AadamDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
J R TriggsDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
A BapayeDepartment of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
S DorwatDepartment of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
P BeniasDivision of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, NY, USA.
D M ChavesGastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
M BarretGastroenterology Unit, Cochin University Hospital, Université Paris Descartes, Paris, France.
R J LawUniversity of Michigan Health Care System, Ann Arbor, USA.
N BrowersUniversity of Michigan Health Care System, Ann Arbor, USA.
M PiocheService d'Hépato-gastro-entérologie, Hôpital Edouard Herriot, CHU Lyon, Lyon, France.
P V DraganovDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL, USA.
A KotzevClinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
F EstremeraClinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
E AlbenizDivision of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
M B UjikiSection of Minimally Invasive Surgery, Department of Surgery, NorthShore University Health System, Evanston, IL, USA.
Z M CallahanSection of Minimally Invasive Surgery, Department of Surgery, NorthShore University Health System, Evanston, IL, USA.
M I ItaniDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
O G BrewerDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
M A KhashabDivision of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA. mkhasha1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric peroral endoscopic myotomy (G-POEM) has emerged as an effective management approach for patients with refractory gastroparesis. This study aims to comprehensively study the safety of G-POEM and describe the predictive factors of adverse events (AEs) occurrence.

methodsThis study is a retrospective study involving 13 tertiary care centers (7 USA, 1 South America, 4 Europe, and 1 Asia). Patients who underwent G-POEM for refractory gastroparesis were included. Cases were identified by the occurrence of AEs. For each case, two controls were randomly selected and matched for age (± 10 years), gender, and etiology of gastroparesis.

resultsA total of 216 patients underwent G-POEM for gastroparesis. Overall, 31 (14%) AEs were encountered [mild 24 (77%), moderate 5 (16%), and severe 2 (6%)] during the duration of the study. The most common AE was abdominal pain (n = 16), followed by mucosotomy (n = 5) and capnoperitoneum (n = 4), and AEs were most commonly identified within the first 48-h post-procedure 18 (58%). The risk of adverse event occurrence was significantly higher for endoscopists with experience of < 20 G-POEM procedures (OR 3.03 [1.03-8.94], p < 0.05).

conclusionG-POEM seems to be a safe intervention for refractory gastroparesis. AEs are most commonly mild and managed conservatively. Longitudinal mucosal incision, use of hook knife, use of clips for mucosal closure and endoscopist's experience with > 20 G-POEM procedures is significantly associated with decreased incidence of AEs.

Indexed as

InternationalityAdultCase-Control StudiesFemaleGastroparesisHumansMaleMiddle AgedPhysiciansPyloromyotomyRetrospective StudiesTime FactorsTreatment OutcomeAdverse eventsGastric peroral endoscopic myotomyGastroparesisG-POEM

Identifiers

PMID32328824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.