ArticleDysphagia2021
Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.
Article in Dysphagia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- A ducted, biomimetic nipple replicates breastfeeding mechanics through ontogeny in an infant animal model.Pediatric research · 2026Article
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Evaluating the Impact of Nipple Design on Tongue Function in Infant Feeding Using a Dynamic Endocast.Integrative and comparative biology · 2025Article
- Regional Heterogeneity in the Electromyography Activity of Extrinsic Tongue Muscles Is Critical to Tongue Function.Integrative and comparative biology · 2025Article
- Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.The Laryngoscope · 2025Article
- A Machine Learning Pipeline for Automated Bolus Segmentation and Area Measurement in Swallowing Videofluoroscopy Images of an Infant Pig Model.Dysphagia · 2025Article
- Fluid flow and feeding performance in infant mammals: evaluating the impact of nipple design.The Journal of experimental biology · 2025Article
- Infant pigs demonstrate motor adaptation across multiple physiologic functions during feeding in response to dynamic changes in milk flow rate.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A Ducted, Biomimetic Nipple Improves Aspects of Infant Feeding Physiology and Performance in an Animal Model.Dysphagia · 2025Article
- Age-Related Changes in Marmoset (Callithrix jacchus) Feeding Behavior and Physiology: Insights of Masticatory and Swallowing Functions.American journal of primatology · 2025Article
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- Longitudinal Changes in Aerodigestive Responses to Varying Nipple Properties in Infant Pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model.Dysphagia · 2024Article
- Biomechanical and Cortical Control of Tongue Movements During Chewing and Swallowing.Dysphagia · 2024Review
- Mapping research trends regarding the mechanism of dysphagia from 1993 to 2023: a bibliometrics study and visualization analysis.Frontiers in neurology · 2024Review
- Evolution, diversification and function of the maternal-infant dyad in mammalian feeding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model.Journal of texture studies · 2023Article
- Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Feeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with bolus volume. Yet, whether and how bolus volume impacts swallow safety in infant feeding is unknown. A further complication for safe infant swallowing is recurrent laryngeal nerve (RLN) injury due to patent ductus arteriosus surgery, which exacerbates the issues that preterm infants face and can increase the risk of dysphagia. Here, we used a validated animal model feeding freely to test the effect of preterm birth, postnatal maturation and RLN lesion and their interactions on swallow safety. We also tested whether bolus size differed with lesion or birth status, and the relationship between bolus size and swallow safety. We found very little effect of lesion on swallow safety, and preterm infants did not experience more penetration or aspiration than term infants. However, term infants swallowed larger boluses than preterm infants, even after correcting for body size. Bolus size was the primary predictor of penetration or aspiration, with larger boluses being more likely to result in greater degrees of dysphagia irrespective of age or lesion status. These results highlight that penetration and aspiration are likely normal occurrences in infant feeding. Further, when comorbidities, such as RLN lesion or preterm birth are present, limiting bolus size may be an effective means to reduce incidences of penetration and aspiration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.