ArticleWorld journal of surgery2020
Major Variation in the Incidence of Appendicitis Before, During and After Pregnancy: A Population-Based Cohort Study.
Article in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- SAGES guidelines for the use of laparoscopy during pregnancy.Surgical endoscopy · 2024Guideline
- Article
- Association of Sex, Age, and Inflammatory Cell Counts with Complicated Acute Appendicitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Predictors of true appendicitis in pregnancy: a pathology-based 10-year cohort study.BMC surgery · 2025Article
- A Case of Post-Partum Afebrile Perforated Appendicitis: A Diagnostic Dilemma.Clinical case reports · 2025Article
- Associations between Th1-related cytokines and complicated pediatric appendicitis.Scientific reports · 2024Article
- Clinical and pathologic characteristics of appendiceal neuroendocrine neoplasms diagnosed during pregnancy.Frontiers in endocrinology · 2023Article
- An Evaluation of Serum IgE and Th2-Associated Interleukins in Children With Uncomplicated and Complicated Appendicitis.Frontiers in pediatrics · 2022Article
- Are Cesarean Section and Appendectomy in Pregnancy and Puerperium Interrelated? A Cohort Study.Frontiers in surgery · 2022Article
- Nationwide paediatric cohort study of a protective association between allergy and complicated appendicitis.The British journal of surgery · 2021Article
- Pregnant patients requiring emergency general surgery: a scoping review of diagnostic and management strategies.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies indicate a low incidence of appendicitis in third-trimester pregnancy, suggesting a protecting effect of pregnancy. This large population-based cohort study analyzes the association of appendicitis with pregnancy in more detail. The aim of the study was to investigate the incidence of appendicitis and negative appendectomy before, during and after pregnancy.
methodsCross-linking between two Swedish health registries provided data on appendectomy for all women in Sweden giving birth between 1973 and 2013. We analyzed the incidence rates (IR) of perforated and non-perforated appendicitis and negative appendectomy before, during and after pregnancy, and secular trends during the study period. Standardized incidence ratios (SIR) were estimated using age-, sex- and period-specific IR from the background population in Sweden.
resultsSome 3,888,452 pregnancies resulted in birth during the study period. An appendectomy was registered for 27,575 women in the interval starting one year before and ending two years after pregnancy. The incidence of appendicitis varied substantially during and after pregnancy. SIR for perforated appendicitis was 0.47 (95% CI 0.38-0.59) in the third trimester, 3.89 (2.92-5.18) peripartum, 2.20 (1.89-2.55) in the puerperium and 1.27 (1.19-1.36) in the year postpartum. The pattern was similar for non-perforated appendicitis. Negative appendectomy decreased postpartum. Incidence rate of non-perforated appendicitis and negative appendectomy decreased for both pregnant and non-pregnant women during the study period.
conclusionsThe findings in this study suggest a protecting effect of pregnancy on the development of appendicitis, which is followed by a rebound effect after birth.
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