ArticleCurrent microbiology2020
Using Various Approaches of Design of Experiments for High Cell Density Production of the Functionally Probiotic Lactobacillus plantarum Strain RPR42 in a Cane Molasses-based Medium.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- B-vitamin supplementation unlocks DHA production of Aurantiochytrium limacinum on molasses-based fermentation residue.Applied microbiology and biotechnology · 2026Article
- Heat-KilledAnimals : an open access journal from MDPI · 2024Article
- Design of an agro-industrial by-products-based media for the production of probiotic bacteria for fish nutrition.Scientific reports · 2024Article
- Article
- Production of a potential multistrain probiotic in co-culture conditions using agro-industrial by-products-based medium for fish nutrition.BMC biotechnology · 2023Article
- Article
- Alternative culture medium design for biomass production of autochthonous meat starter Latilactobacillus sakei sp. sakei ACU-2.Scientific reports · 2023Article
- Characterization, High-Density Fermentation, and the Production of a Directed Vat Set Starter ofFoods (Basel, Switzerland) · 2022Review
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Authors and funding
6 authors.
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Abstract
Considering the economic importance of the probiotics, industrial production of their biomass became important. Cane molasses, as an industrial byproduct, was used in this study to design a medium for biomass overproduction of a functionally probiotic strain, designated as Lactobacillus plantarum strain RPR42. The results showed that strain RPR42 can be best grown anaerobically in 22.5% cane molasses solution. Also, the findings of the single variable at a time experiments and either factorial design indicated that the optimal growth of strain RPR42 can be observed when beef extract, casein hydrolysate, and yeast extract were added into the medium. The central composite design experiments suggested a medium which was designated as cane molasses medium (CMM). Eventually, this medium contained 21.9% cane molasses, 30.72 g/L of a combined mixture of nitrogenous compounds: 0.0754% of a 1:1:1 mixture of polysorbates 20, 60, and 80, and 18.53 gr/L of the combined minerals. Such an optimized cane molasses-based medium supported a significant biomass production since a considerably high cell density, 13.8 g/L/24 h of dry biomass, of the strain was produced. Hence, cane molasses can be regarded as a promising substrate for industrial production purposes.
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Registered trials
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