Evidence map›Paper›PMID 32328746›Full record

ArticleEuropean journal of nutrition2021

Protective effects of bovine milk exosomes against oxidative stress in IEC-6 cells.

Lanfang Wang, Zhexi Shi, Xinyan Wang, Shu Mu, Xiaoyan Xu, Li Shen, Ping Li

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 70 citations in OpenAlex.

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  15. Review
  16. Exosome is a Fancy Mobile Sower of Ferroptosis.Journal of cardiovascular translational research · 2024
    Review
  17. Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lanfang WangResearch Center for Translational Medicine at Shanghai East Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, People's Republic of China. lanfangwlf@tongji.edu.cn.
Zhexi ShiResearch Center for Translational Medicine at Shanghai East Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, People's Republic of China.
Xinyan WangThe People's Hospital of Zhaoyuan City, Zhaoyuan, 265400, Shandong Province, China.
Shu MuResearch Center for Translational Medicine at Shanghai East Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, People's Republic of China.
Xiaoyan XuResearch Center for Translational Medicine at Shanghai East Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, People's Republic of China.
Li ShenDepartment of Pathogen Biology, Tongji University School of Medicine, Shanghai, 200092, China.
Ping LiResearch Center for Translational Medicine at Shanghai East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Shanghai East Hospital · CNThe First People's Hospital of Zhaoqing · CNTongji University · CN

Funding

International Science and Technology Cooperation Programs of Anhui 1503062006National Key Technology R&D Program of China 2015BAD16B01National Natural Science Foundation of China 21476176
6 · The paper itself

Abstract

purposeBovine milk exosomes, which are enriched with microRNAs (miRNAs) and proteins, regulate immune response and growth. In the present study, we aimed to assess the protective effects of bovine milk exosomes against oxidative stress of intestinal crypt epithelial cells (IEC-6).

methodsBovine milk exosomes were isolated and characterized. To assess the protective effects of exosomes, IEC-6 cells were pretreated with exosomes, followed by H

resultsThe isolated bovine milk exosome were positive for CD63 and CD9 expression. The exosomes were approximately circular and had a diameter of about 67.23 nm. Pretreatment of IEC-6 cells with bovine milk exosomes enhanced cell viability; increased SOD and GPX activities; and reduced LDH, ROS, and MDA levels after H

conclusionThe results indicated that bovine milk exosomes exerted protective effects against oxidative stress in IEC-6 cells.

Indexed as

ExosomesMilkAnimalsAntioxidantsCattleHeme Oxygenase-1Hydrogen PeroxideNF-E2-Related Factor 2Oxidative StressReactive Oxygen SpeciesAntioxidantsHeme Oxygenase-1Hydrogen PeroxideNF-E2-Related Factor 2Reactive Oxygen SpeciesExosomesHO-1IEC-6 cellsmicroRNANRF2Oxidative stress

Identifiers

PMID32328746
OpenAlexW3018504305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.