Evidence map›Paper›PMID 32328577›Full record

ArticleBrain communications2020

Brain phenotyping in Moebius syndrome and other congenital facial weakness disorders by diffusion MRI morphometry.

Neda Sadeghi, Elizabeth Hutchinson, Carol Van Ryzin, Edmond J FitzGibbon, John A Butman, Bryn D Webb, Flavia Facio, Brian P Brooks, Francis S Collins, Ethylin Wang Jabs and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03059420 (Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03059420 recruitingnot on this map

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

TypeobservationalSponsorBoston Children's HospitalRan2004 to 2030Enrolled20,000ConditionsCongenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Multimodality Craniofacial Phenotyping of Congenital Facial Weakness Disorders.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Neda SadeghiQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5213-1614
Elizabeth HutchinsonQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3374-5469
Carol Van RyzinMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Edmond J FitzGibbonOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
John A ButmanRadiology & Imaging Sciences Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Bryn D WebbDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Flavia FacioMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Brian P BrooksOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ethylin Wang JabsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Elizabeth C EngleDepartment of Neurology and Department of Ophthalmology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0760-4491
Irini ManoliMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Carlo PierpaoliQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8558-4428
Moebius Syndrome Research Consortium
Boston Children's Hospital · USNational Institutes of Health · USIcahn School of Medicine at Mount Sinai · USNational Institute of Mental Health · USNational Institute of Dental and Craniofacial Research · USNational Institutes of Health Clinical Center · USBrigham and Women's Hospital · USNational Human Genome Research Institute · US

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Neuro-ophthalmic Mechanisms Of DiseaseZIAEY000388 · NEI · NATIONAL EYE INSTITUTE · PI FITZGIBBON, EDMOND J · 2009 to 2023
$5.1M
Genetics of Moebius syndrome and other congenital facial weakness disordersZIAHG200389 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 2013 to 2024
$4.9M
Birth Defects: Moebius syndrome and related facial weakness disordersU01HD079068 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BROOKS, BRIAN PATRICK, ENGLE, ELIZABETH C. · 2014 to 2016
$1.1M
NICHD NIH HHS U01 HD079068NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

In this study, we used a novel imaging technique, DTI (diffusion tensor imaging)-driven tensor-based morphometry, to investigate brain anatomy in subjects diagnosed with Moebius syndrome (

Indexed as

brainstem, DTI, DTBM, magnetic resonance imaging, quantitative

Identifiers

PMID32328577
PMCPMC7158234
OpenAlexW3005997805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.