Evidence map›Paper›PMID 32328469›Full record

ReviewFrontiers in cellular and infection microbiology2020

Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices.

Qiang Tang, Ge Jin, Gang Wang, Tianyu Liu, Xiang Liu, Bangmao Wang, Hailong Cao

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06355583 (Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant), which is not on this map. Cited by 246 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06355583 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

TypeinterventionalSponsorImperial College LondonRan2024 to 2027Enrolled50ConditionsAcute Lymphoblastic Leukaemia, Acute Leukemia of Ambiguous Lineage, Chronic Myeloid Leukemia, Chronic Myelomonocytic LeukemiaArmsEBX-102, Placebo
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Microbiome Composition in Microscopic Colitis: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Article
  12. Gut protist diversity in Eurasian beavers (International journal for parasitology. Parasites and wildlife · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. The Microbiota in the Diagnosis and Treatment of Autism Spectrum Disorder.International journal of molecular sciences · 2026
    Review
  20. Article

186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang TangDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Ge JinDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Gang WangTianjin Institute of Digestive Disease, General Hospital, Tianjin Medical University, Tianjin, China.
Tianyu LiuDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Xiang LiuDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Bangmao WangDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Hailong CaoDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of next-generation sequencing technology has enabled researchers to explore and understand the gut microbiome from a broader and deeper perspective. However, the results of different studies on gut microbiota are highly variable even in the same disease, which makes it difficult to guide clinical diagnosis and treatment. The ideal sampling method should be non-invasive, involve little cross-contamination or bowel preparation, and collect gut microbiota at different sites. Currently, sequencing technologies are usually based on samples collected from feces, mucosal biopsy, intestinal fluid, etc. However, different parts of the gastrointestinal tract possess various physiological characteristics that are essential for particular species of living microbiota. Moreover, current sampling methods are somewhat defective. For example, fecal samples are just a proxy for intestinal microbiota, while biopsies are invasive for patients and not suitable for healthy controls. In this review, we summarize the current sampling methods and their advantages and shortcomings. New sampling technologies, such as the Brisbane Aseptic Biopsy Device and the intelligent capsule, are also mentioned to inspire the development of future precise description methods of the gut microbiome.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaFecesGastrointestinal TractHumansIntestinesaspiratebiopsyfecesgut microbiotasampling methods

Identifiers

PMID32328469
PMCPMC7161087

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.