Evidence map›Paper›PMID 32328438›Full record

ArticleNanotheranostics2020

Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer.

Eleanor McCabe-Lankford, Bryce McCarthy, Margarita Arakelyan-Peters Berwick, Kiarash Salafian, Laura Galarza-Paez, Santu Sarkar, John Sloop, George Donati, April J Brown, Nicole Levi-Polyachenko

Open access · goldAbstract read
In one paragraph

Article in Nanotheranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eleanor McCabe-LankfordDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Bryce McCarthyDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Margarita Arakelyan-Peters BerwickDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Kiarash SalafianDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Laura Galarza-PaezDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Santu SarkarDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
John SloopDepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
George DonatiDepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
April J BrownDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Nicole Levi-PolyachenkoDepartment of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Wake Forest University · US

Funding

Conductive Polymer Nanoparticles for Treatment of Colorectal Cancer MetastasisR21EB019748 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEVI, NICOLE H · 2014 to 2015
$419k
NIBIB NIH HHS R21 EB019748
6 · The paper itself

Abstract

Nanoparticles offer many promising advantages for improving current surgical regimens through their ability to detect and treat disseminated colorectal cancer (CRC). Hybrid Donor-Acceptor Polymer Particles (HDAPPs) have recently been shown to fluorescently detect and thermally ablate tumors in a murine model. Here, HDAPPS were functionalized with hyaluronic acid (HA) to improve their binding specificity to CT26 mouse CRC cells using HA to target the cancer stem cell marker CD44. In this work, we compared the binding of HA functionalized HDAPPs (HA-HDAPPs) in

Indexed as

Antineoplastic AgentsColorectal NeoplasmsQuantum DotsAnimalsCell Line, TumorDrug Delivery SystemsFluorescent DyesHyaluronic AcidMiceOptical ImagingPeritoneal CavityTheranostic NanomedicineAntineoplastic AgentsFluorescent DyesHyaluronic Aciddisseminated colorectal cancerHDAPPSHybrid Donor-Acceptor Polymer Particlesnanoparticles

Identifiers

PMID32328438
PMCPMC7171385
OpenAlexW3015706631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.