Evidence map›Paper›PMID 32328435›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

From Sequence-Defined Macromolecules to Macromolecular Pin Codes.

Joshua O Holloway, Filip Van Lijsebetten, Nezha Badi, Hannes A Houck, Filip E Du Prez

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Photo-Accelerated Synthesis of Oligo(triazole amide)s.Macromolecular rapid communications · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. From Sequence-Defined Macromolecules to Macromolecular Pin Codes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua O HollowayPolymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.ORCID https://orcid.org/0000-0002-6631-5502
Filip Van LijsebettenPolymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.
Nezha BadiPolymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.ORCID https://orcid.org/0000-0003-4220-571X
Hannes A HouckPolymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.ORCID https://orcid.org/0000-0001-7602-3784
Filip E Du PrezPolymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.ORCID https://orcid.org/0000-0001-7727-4155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic sequence-defined oligomers carrying a chemically written pin code are obtained through a strategy combining multicomponent reactions with the thermoreversible addition of 1,2,4-triazoline-3,5-diones (TADs) to indole substrates. The precision oligomers are specifically designed to be encrypted upon heating as a result of the random reshuffling of the TAD-indole covalent bonds within the backbone, thereby resulting in the scrambling of the encoded information. The encrypted pin code can eventually be decrypted following a second heating step that enables the macromolecular pin code to be deciphered using 1D electrospray ionization-mass spectrometry (ESI-MS). The herein introduced concept of encryption/decryption represents a key advancement compared with current strategies that typically use uncontrolled degradation to erase and tandem mass spectrometry (MS/MS) to analyze, decipher, and read-out chemically encrypted information. Additionally, the synthesized macromolecules are coated onto a high-value polymer material, which demonstrates their potential application as coded product tags for anti-counterfeiting purposes.

Indexed as

1,2,4‐triazoline‐3,5‐dionechemical encryptionmulticomponent reactionssequence‐defined macromolecules

Identifiers

PMID32328435
PMCPMC7175230

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.