Evidence map›Paper›PMID 32328427›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.

Anna Kletzmayr, Shrikant R Mulay, Manga Motrapu, Zhi Luo, Hans-Joachim Anders, Mattias E Ivarsson, Jean-Christophe Leroux

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Tartronic Acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Novel therapeutic approaches for the primary hyperoxalurias.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  16. Review
  17. Article
  18. Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Anna KletzmayrInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland.
Shrikant R MulayDivision of Nephrology Department of Medicine IV University Hospital LMU Munich 80336 Munich Germany.
Manga MotrapuDivision of Nephrology Department of Medicine IV University Hospital LMU Munich 80336 Munich Germany.
Zhi LuoInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland.
Hans-Joachim AndersDivision of Nephrology Department of Medicine IV University Hospital LMU Munich 80336 Munich Germany.
Mattias E IvarssonInositec Inc. 8005 Zurich Switzerland.
Jean-Christophe LerouxInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland.ORCID https://orcid.org/0000-0001-5601-1292
ETH Zurich · CHLMU Klinikum · DEDepartment of Health Canton of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium oxalate (CaOx) crystal-induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Although CaOx crystallization inhibitors have been suggested as a therapeutic modality already decades ago, limited progress has been made in the discovery of potent molecules with efficacy in animal disease models. Herein, an image-based machine learning approach to systematically screen chemically modified

Indexed as

calcium oxalate crystallization inhibitorschronic kidney diseaseimage‐based drug screeningkidney calcificationkidney stones

Identifiers

PMID32328427
PMCPMC7175250
OpenAlexW3008925488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.