Evidence map›Paper›PMID 32328356›Full record

ArticlePeerJ2020

Proteomic profiling analysis of postmenopausal osteoporosis and osteopenia identifies potential proteins associated with low bone mineral density.

Dageng Huang, Yangyang Wang, Jing Lv, Yuzhu Yan, Ya Hu, Cuicui Liu, Feng Zhang, Jihan Wang, Dingjun Hao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Dageng HuangDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Yangyang WangSchool of Electronics and Information, Northwestern Polytechnical University, Xi'an, China.
Jing LvClinical Laboratory of Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0003-2801-743X
Yuzhu YanClinical Laboratory of Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Ya HuDepartment of Physiology, Hunan Polytechnic of Environment and Biology, Hengyang, China.
Cuicui LiuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Feng ZhangSchool of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Jihan WangClinical Laboratory of Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Dingjun HaoDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Xi'an Honghui Hospital · CNHunan Institute of Technology · CNNorthwestern Polytechnical University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis (PMOP) is a major global public health concern and older women are more susceptible to experiencing fragility fractures. Our study investigated the associations between circulating proteins with bone mineral density (BMD) in postmenopausal women with or without low BMD (osteoporosis and osteopenia) using a tandem mass tag (TMT) labeling proteomic experiment and parallel reaction monitoring testing. Across all plasma samples, we quantitatively measured 1,092 proteins, and the OP and normal control (NC) samples were differentiated by principal component analysis and a partial least squares-discrimination analysis model based on the protein profiling data. The differentially abundant proteins between the low BMD and NC samples mostly exhibited binding, molecular function regulator, transporter and molecular transducer activity, and were involved in metabolic and cellular processes, stimulus response, biological regulation, immune system processes and so forth. TMT analysis and RRM validation indicated that the expression of protein Lysozyme C (P61626) was negatively related to BMD, while the expression of proteins Glucosidase (A0A024R592) and Protein disulfideisomerase A5 (Q14554) was positively related to BMD values. Collectively, our results suggest that postmenopausal women with low BMD have a different proteomic profile or signature. Protein alterations may play an important role in the pathogenesis of PMOP, and they may act as novel biomarkers and targets of therapeutic agents for this disease.

Indexed as

Bone mineral densityDiagnostic biomarkersPostmenopausal osteoporosisPRMProteomicsTherapeutic targetsTMT

Identifiers

PMID32328356
PMCPMC7164430
OpenAlexW3016589303

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.