ArticlePeerJ2020
Disturbed neurovascular coupling in hemodialysis patients.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Altered brain activity in patients with end-stage renal disease: A meta-analysis of resting-state functional imaging.Brain and behavior · 2023Pooled it
- Alterations of amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations in end-stage renal disease on maintenance dialysis: An activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2022Pooled it
- Neurovascular decoupling is associated with altered glymphatic function as assessed by the DTI-ALPS index in patients on dialysis.Brain imaging and behavior · 2026Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Abnormal neurovascular coupling exists in patients with peritoneal dialysis and hemodialysis: evidence from a multi-mode MRI study.Clinical kidney journal · 2025Article
- Multiparameter neuroimaging study of neurovascular coupling changes in patients with end-stage renal disease.Brain and behavior · 2024Article
- Altered spontaneous brain activities in maintenance hemodialysis patients with cognitive impairment and the construction of cognitive function prediction models.Renal failure · 2023Article
- Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition.Human brain mapping · 2022Article
- Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity.Cell reports methods · 2022Article
- Article
- Aberrant neurovascular coupling in Leber's hereditary optic neuropathy: Evidence from a multi-model MRI analysis.Frontiers in neuroscience · 2022Article
- Increased cerebral blood flow is correlated with neurocognitive impairment in long-term hemodialysis patients: an arterial spin labeling MRI study.Brain imaging and behavior · 2021Article
- Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity Strength in Cervical Spondylotic Myelopathy Patients.Frontiers in neurology · 2021Article
- Review of the structural and functional brain changes associated with chronic kidney disease.Physiological research · 2020Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAltered cerebral blood flow (CBF) and amplitude of low-frequency fluctuation (ALFF) have been reported in hemodialysis patients. However, neurovascular coupling impairments, which provide a novel insight into the human brain, have not been reported in hemodialysis patients.
methodsWe combined arterial spin labeling (ASL) and blood oxygen level dependent (BOLD) techniques to investigate neurovascular coupling alterations and its relationships with demographic and clinical data in 46 hemodialysis patients and 47 healthy controls. To explore regional neuronal activity, ALFF was obtained from resting-state functional MRI. To measure cerebral vascular response, CBF was calculated from ASL. The across-voxel CBF-ALFF correlations for global neurovascular coupling and CBF/ALFF ratio for regional neurovascular coupling were compared between hemodialysis patients and healthy controls. Two-sample
resultsAll hemodialysis patients and healthy controls showed significant across-voxel correlations between CBF and ALFF. Hemodialysis patients showed a significantly reduced global CBF-ALFF coupling (
conclusionsThese novel findings reveal that disrupted neurovascular coupling may be a potential neural mechanism in hemodialysis patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.