ArticleBiotechnology for biofuels2020
From Eat to trEat: engineering the mitochondrial Eat1 enzyme for enhanced ethyl acetate production in
Article in Biotechnology for biofuels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Genomic analysis ofMicrobial genomics · 2023Article
- Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus.Applied microbiology and biotechnology · 2023Article
- Metabolic engineering of Clostridium autoethanogenum for ethyl acetate production from CO.Microbial cell factories · 2022Article
- Co-production of hydrogen and ethyl acetate in Escherichia coli.Biotechnology for biofuels · 2021Article
- Synthesis of ethyl acetate from glucose byEngineering in life sciences · 2021Article
- A new approach for balancing the microbial synthesis of ethyl acetate and other volatile metabolites during aerobic bioreactor cultivations.Engineering in life sciences · 2021Article
- Multilevel optimisation of anaerobic ethyl acetate production in engineeredBiotechnology for biofuels · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic engineering of microorganisms has become a common practice to establish microbial cell factories for a wide range of compounds. Ethyl acetate is an industrial solvent that is used in several applications, mainly as a biodegradable organic solvent with low toxicity. While ethyl acetate is produced by several natural yeast species, the main mechanism of production has remained elusive until the discovery of Eat1 in
resultsUnprocessed and synthetically truncated eat1 variants of
conclusionBy analysing and predicting the N-terminal pre-sequences of different Eat1 proteins and systematically trimming them, the stability of the enzymes in vitro could be improved, leading to an overall improvement of in vivo ethyl acetate production in
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Registered trials
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